Eosinophil transendothelial migration induced by the bronchoalveolar lavage fluid of acute eosinophilic pneumonia

• Published in: Respirology (Carlton, Vic.) Vol. 22; no. 5; pp. 913 - 921
• Main Authors: Nakagome, Kazuyuki, Shoda, Hisakazu, Shirai, Tetsu, Nishihara, Fuyumi, Soma, Tomoyuki, Uchida, Yoshitaka, Sakamoto, Yoshio, Nagata, Makoto
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.07.2017; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Aged; allergy; Alveoli; Alveolitis; Alveolitis, Extrinsic Allergic - immunology; Bronchoalveolar Lavage Fluid; Bronchus; Case-Control Studies; Chemokine CCL24 - immunology; Chemokines; Chemokines - immunology; cytokine; Cytokines; Cytokines - immunology; Endothelial cells; eosinophil; Eosinophils - immunology; Eotaxin; Female; Filters; Humans; Hypersensitivity; interstitial lung disease; Leukocyte Count; Leukocyte migration; Leukocytes (eosinophilic); Ligands; Male; Microvasculature; Middle Aged; Monocyte Chemoattractant Proteins - immunology; Monocytes; Pneumonia; Pneumonitis; Pulmonary Eosinophilia - immunology; Receptors, CCR3 - immunology; Respiratory diseases; Sarcoidosis; Sarcoidosis, Pulmonary - immunology; Transendothelial and Transepithelial Migration - immunology; Young Adult; cytokine; allergy; sarcoidosis; eosinophil; interstitial lung disease

ABSTRACT Background and objective Acute eosinophilic pneumonia (AEP) is characterized by a massive pulmonary infiltration of eosinophils. Mechanisms regulating the selective accumulation of eosinophils in AEP have not been fully established. The objective of this study was to evaluate the mechanisms...