Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany

• Published in: Molecular carcinogenesis Vol. 49; no. 10; pp. 869 - 873
• Main Authors: Gao, Lei, Weck, Melanie N., Nieters, Alexandra, Brenner, Hermann
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2010
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Aged; Carcinogenesis; Case-Control Studies; chronic atrophic gastritis; Chronic infection; Cohort Studies; Enzyme-linked immunosorbent assay; Female; Gab1 gene; Gastritis; Gastritis, Atrophic - blood; Gastritis, Atrophic - genetics; Gene polymorphism; genetic polymorphism; Genotype; Germany - epidemiology; Grb2-associated binder 1; Helicobacter Infections - genetics; Helicobacter Infections - immunology; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - immunology; Humans; Male; Middle Aged; Pepsinogen A - blood; Pepsinogen A - genetics; Polymorphism, Single Nucleotide; Population studies; Single-nucleotide polymorphism; Transformation; Germany

Grb2‐associated binder 1 (Gab1) plays an important role in the regulation of cell growth and transformation. A single nucleotide polymorphism (SNP) (rs3805246) in the Gab1 gene has been suggested to be related to the risk of Helicobacter pylori infection and chronic atrophic gastritis (CAG) in a stu...