Transposable Elements in Pluripotent Stem Cells and Human Disease

• Published in: Frontiers in genetics Vol. 13; p. 902541
• Main Authors: Ma, Gang, Babarinde, Isaac A., Zhou, Xuemeng, Hutchins, Andrew P.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 02.06.2022
• Subjects: endogenous retrovirus (ERV); Genetics; long terminal repeat (LTR); non-coding RNA (ncRNAs); pluripotent stem cell (PSC); transposable element (TE)

Transposable elements (TEs) are mobile genetic elements that can randomly integrate into other genomic sites. They have successfully replicated and now occupy around 40% of the total DNA sequence in humans. TEs in the genome have a complex relationship with the host cell, being both potentially dele...