The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress

The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans‐NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in‐d...

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Published inAnnals of the New York Academy of Sciences Vol. 1285; no. 1; pp. 133 - 147
Main Authors Dickler, Howard B., McCoy, J. Philip, Nussenblatt, Robert, Perl, Shira, Schwartzberg, Pamela A., Tsang, John S., Wang, Ena, Young, Neil S.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.05.2013
Wiley Subscription Services, Inc
Subjects
Allergy and Immunology - history
Autoimmune Diseases - history
Autoimmune Diseases - pathology
autoimmunity
Gene expression
History, 21st Century
human
Humans
Immunology
inflammation
Inflammation - history
Inflammation - pathology
Influenza Vaccines - history
Medical research
National Institutes of Health (U.S.) - history
National Institutes of Health (U.S.) - organization & administration
United States
Vaccination - history
United States
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Abstract The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans‐NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in‐depth assessment of the human immune system using high‐throughput multiplex technologies for examination of immune cells and their products, the genome, gene expression, and epigenetic modulation obtained from individuals both before and after interventions, adding information from in‐depth clinical phenotyping, and then applying advanced biostatistical and computer modeling methods for mining these diverse data. The aim is to develop a comprehensive picture of the human “immunome” in health and disease, elucidate common pathogenic pathways in various diseases, identify and validate biomarkers that predict disease progression and responses to new interventions, and identify potential targets for new therapeutic modalities. Challenges, opportunities, and progress are detailed.
AbstractList The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans-NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in-depth assessment of the human immune system using high-throughput multiplex technologies for examination of immune cells and their products, the genome, gene expression, and epigenetic modulation obtained from individuals both before and after interventions, adding information from in-depth clinical phenotyping, and then applying advanced biostatistical and computer modeling methods for mining these diverse data. The aim is to develop a comprehensive picture of the human "immunome" in health and disease, elucidate common pathogenic pathways in various diseases, identify and validate biomarkers that predict disease progression and responses to new interventions, and identify potential targets for new therapeutic modalities. Challenges, opportunities, and progress are detailed.
The Center for Human Immunology, Autoimmunity, and Inflammation (CHI) is an exciting initiative of the NIH intramural program begun in 2009. It is uniquely trans-NIH in support (multiple institutes) and leadership (senior scientists from several institutes who donate their time). Its goal is an in-depth assessment of the human immune system using high-throughput multiplex technologies for examination of immune cells and their products, the genome, gene expression, and epigenetic modulation obtained from individuals both before and after interventions, adding information from in-depth clinical phenotyping, and then applying advanced biostatistical and computer modeling methods for mining these diverse data. The aim is to develop a comprehensive picture of the human "immunome" in health and disease, elucidate common pathogenic pathways in various diseases, identify and validate biomarkers that predict disease progression and responses to new interventions, and identify potential targets for new therapeutic modalities. Challenges, opportunities, and progress are detailed. [PUBLICATION ABSTRACT]
Author Schwartzberg, Pamela A.
Perl, Shira
Nussenblatt, Robert
Young, Neil S.
Dickler, Howard B.
McCoy, J. Philip
Wang, Ena
Tsang, John S.
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  organization: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Maryland, Bethesda
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Cites_doi 10.1038/nri3158
10.1056/NEJMoa0807646
10.1158/1078-0432.CCR-07-5162
10.1158/1078-0432.CCR-06-0268
10.1016/j.bbmt.2008.12.494
10.1016/j.jim.2010.06.010
10.1056/NEJMoa1103975
10.1038/nmeth.2365
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SubjectTerms Allergy and Immunology - history
Autoimmune Diseases - history
Autoimmune Diseases - pathology
autoimmunity
Gene expression
History, 21st Century
human
Humans
Immunology
inflammation
Inflammation - history
Inflammation - pathology
Influenza Vaccines - history
Medical research
National Institutes of Health (U.S.) - history
National Institutes of Health (U.S.) - organization & administration
United States
Vaccination - history
Title The National Institutes of Health Center for Human Immunology, Autoimmunity, and Inflammation: history and progress
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