Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma

• Published in: The Laryngoscope
• Main Authors: Komune, Noritaka, Sato, Kuniaki, Hongo, Takahiro, Miyazaki, Masaru, Masuda, Shogo, Koike, Kensuke, Uchi, Ryutaro, Tsuchihashi, Nana Akagi, Noda, Teppei, Kogo, Ryunosuke, Wakasaki, Takahiro, Yasumatsu, Ryuji, Nakagawa, Takashi
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: overall survival; prognostic marker; Temporal bone; inflammatory marker; squamous cell carcinoma
• ISSN: 1531-4995
• DOI: 10.1002/lary.29421

Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation-based prognostic scores in cases of temporal bone SCC. Case reries with chart review. A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation-based scores and 5-year overall survival. Univariate Cox regression analyzes showed that a high neutrophil-to-lymphocyte ratio, high platelet-to-lymphocyte ratio, low lymphocyte-to-monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C-reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers. Inflammation-based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs. 4 Laryngoscope, 2021.