Gene–gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol

• Published in: Basic & clinical pharmacology & toxicology Vol. 130; no. 2; pp. 277 - 287
• Main Authors: Oliveira‐Paula, Gustavo H., Pereira, Daniela A., Pinheiro, Lucas C., Ferreira, Graziele C., Paula‐Garcia, Waynice N., Garcia, Luis V., Lacchini, Riccardo, Luizon, Marcelo R., Tanus‐Santos, Jose E.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.02.2022
• Subjects: Adult; Aged; anaesthesia; Anesthesia; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Bioavailability; Blood pressure; Chemiluminescence; Cross-Sectional Studies; Emission measurements; Female; Gene polymorphism; Genotype; Genotypes; Haplotypes; Humans; Hypotension; Hypotension - chemically induced; Hypotension - genetics; Kinases; Male; Middle Aged; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type III - genetics; Nitric-oxide synthase; Nitrites; Polymorphism; Pressure effects; Propofol; Propofol - administration & dosage; Propofol - adverse effects; Protein kinase C; Protein Kinase C-alpha - genetics; Proteins; single nucleotide polymorphisms; blood pressure; nitric oxide; single nucleotide polymorphisms; protein kinase C; anaesthesia

Anaesthesia with propofol is frequently associated with hypotension, which is at least partially attributable to increased nitric oxide (NO) formation derived from the activation of protein kinase C (PKC)/endothelial NO synthase (NOS3) axis. In this cross‐sectional study, we tested whether PRKCA (wh...