Gene–gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol - Oliveira‐Paula, Gustavo H.; Pereira, Daniela A.; Pinheiro, Lucas C.; Ferreira, Graziele C.; Paula‐Garcia, Waynice N.; Garcia, Luis V.; Lacchini, Riccardo; Luizon, Marcelo R.; Tanus‐Santos, Jose E. (Basic & clinical pharmacology & toxicology, 2022)
Keywords: Adult; Aged; anaesthesia; Anesthesia; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Bioavailability; Blood pressure; Chemiluminescence; Cross-Sectional Studies; Emission measurements; Female; Gene polymorphism; Genotype; Genotypes; Haplotypes; Humans; Hypotension; Hypotension - chemically induced; Hypotension - genetics; Kinases; Male; Middle Aged; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type III - genetics; Nitric-oxide synthase; Nitrites; Polymorphism; Pressure effects; Propofol; Propofol - administration & dosage; Propofol - adverse effects; Protein kinase C; Protein Kinase C-alpha - genetics; Proteins; single nucleotide polymorphisms; blood pressure; nitric oxide; single nucleotide polymorphisms; protein kinase C; anaesthesia