Spiro‐2‐oxindoles via 1,3‐dipolar cycloadditions. A decade update

• Published in: European journal of organic chemistry Vol. 2021; no. 11; pp. 1653 - 1675
• Main Authors: Molteni, Giorgio, Silvani, Alessandra
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 19.03.2021
• Subjects: 1,3-Dipolar cycloaddition; 3-Alkylidene-2-oxindoles; 3-Imino-2-oxindoles; Chemical compounds; Cycloaddition; Dipoles; Isatins; Pharmacology; Spiro-2-oxindoles

The great variety of spirooxindole three‐dimensional scaffolds encompasses relevant bioactive natural alkaloids as well as useful therapeutic agents. In view of the challenging features of the spirooxindole skeletons and their desirable properties, several synthetic routes have been devoted to their...