Radiomics Strategy for Molecular Subtype Stratification of Lower‐Grade Glioma: Detecting IDH and TP53 Mutations Based on Multimodal MRI

• Published in: Journal of magnetic resonance imaging Vol. 48; no. 4; pp. 916 - 926
• Main Authors: Zhang, Xi, Tian, Qiang, Wang, Liang, Liu, Yang, Li, Baojuan, Liang, Zhengrong, Gao, Peng, Zheng, Kaizhong, Zhao, Bofeng, Lu, Hongbing
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2018
• Subjects: Attenuation; Correlation coefficients; Data processing; Field strength; Glioma; IDH; Image contrast; Image enhancement; Isocitrate dehydrogenase; lower‐grade glioma; Magnetic resonance imaging; Medical imaging; multimodal MRI; Mutation; p53 Protein; Patients; Population (statistical); Population studies; Radiomics; Scanners; Statistical analysis; Statistical tests; Support vector machines; TP53; Variance analysis; radiomics; IDH; TP53; lower-grade glioma; multimodal MRI

Background Noninvasive detection of isocitrate dehydrogenase (IDH) and TP53 mutations are meaningful for molecular stratification of lower‐grade gliomas (LrGG). Purpose To explore potential MRI features reflecting IDH and TP53 mutations of LrGG, and propose a radiomics strategy for detecting them. S...