Quinuclidine and DABCO Enhance the Radiofluorination of 5‐Substituted 2‐Halopyridines

• Published in: European journal of organic chemistry Vol. 2017; no. 45; pp. 6593 - 6603
• Main Authors: Naumiec, Gregory R., Cai, Lisheng, Lu, Shuiyu, Pike, Victor W.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.12.2017; Wiley Subscription Services, Inc
• Subjects: Additives; Amines; Biomedical materials; Chemistry; Chemistry, Organic; Cyclotrons; Fluoridation; Fluorides; Fluorinated compounds; Fluorine; Halopyridines; Homology; In vivo methods and tests; Labelling; Medical imaging; Medical research; Organocatalysis; Physical Sciences; Positron emission; Radiofluorination; Reactive intermediates; Science & Technology; Substitutes; Tomography; Tracers; Fluorine; ENANTIOMERS; FULLY AUTOMATED RADIOSYNTHESIS; FLUORINATION; Organocatalysis; NUCLEOPHILIC AROMATIC-SUBSTITUTION; POSITRON-EMISSION-TOMOGRAPHY; Reactive intermediates; TRACER; Radiofluorination; Halopyridines; Fluorinated compounds; PET RADIOLIGAND

Positron emission tomography (PET) is an important molecular imaging technique for medical diagnosis, biomedical research and drug development. PET tracers for molecular imaging contain β+‐emitting radionuclides, such as carbon‐11 (t1/2 = 20.4 min) or fluorine‐18 (t1/2 = 109.8 min). The [18F]2‐fluor...