Induction of Interleukin-8 and Interleukin-12 in Neonatal Ovine Lung Following Experimental Inoculation of Bovine Respiratory Syncytial Virus

• Published in: Journal of comparative pathology Vol. 150; no. 4; pp. 434 - 448
• Main Authors: Redondo, E., Gázquez, A., Vadillo, S., García, A., Franco, A., Masot, A.J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2014
• Subjects: Animals; Bovine orthopneumovirus; Bovine respiratory syncytial virus; cytokines; Cytokines - metabolism; immunohistochemistry; inoculum; interferon-gamma; interleukin-10; interleukin-12; Interleukin-12 - metabolism; interleukin-1beta; interleukin-4; interleukin-6; interleukin-8; Interleukin-8 - metabolism; lamb; lambs; lung; Lung - metabolism; Lung - pathology; lungs; necropsy; pathogens; proteins; respiratory rate; Respiratory Syncytial Virus Infections - metabolism; Respiratory Syncytial Virus Infections - pathology; Respiratory Syncytial Virus Infections - veterinary; Respiratory Syncytial Virus, Bovine; Sheep; Sheep Diseases - metabolism; Sheep Diseases - pathology; temperature; tumor necrosis factor-alpha; lung; lamb; cytokines; bovine respiratory syncytial virus

This study aimed to determine the immunohistochemical expression of interleukin (IL)-1β, tumour necrosis factor alpha (TNF)-α, interferon (IFN)-γ, IL-4, IL-6, IL-8, IL-10 and IL-12 and to measure the concentrations of these cytokines in lung tissue from lambs infected experimentally with bovine resp...