Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice

• Published in: Science (American Association for the Advancement of Science) Vol. 371; no. 6534; pp. 1154 - 1159
• Main Authors: Jain, Umang, Ver Heul, Aaron M., Xiong, Shanshan, Gregory, Martin H., Demers, Elora G., Kern, Justin T., Lai, Chin-Wen, Muegge, Brian D., Barisas, Derek A. G., Leal-Ekman, J. Steven, Deepak, Parakkal, Ciorba, Matthew A., Liu, Ta-Chiang, Hogan, Deborah A., Debbas, Philip, Braun, Jonathan, McGovern, Dermot P. B., Underhill, David M., Stappenbeck, Thaddeus S.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 12.03.2021
• Subjects: Amphotericin B - pharmacology; Animals; Anti-Bacterial Agents - pharmacology; Antibiotics; Antifungal Agents - pharmacology; Cell culture; Chemokine CCL5 - metabolism; Colon - microbiology; Colon - pathology; Crohn Disease - immunology; Crohn Disease - microbiology; Crohn Disease - pathology; Crohn's disease; Debaryomyces - growth & development; Debaryomyces - isolation & purification; Debaryomyces - physiology; Debaryomyces hansenii; Digestive system; Female; Food industry; Food processing industry; Fungi; Gastrointestinal Microbiome; Gastrointestinal tract; Germ-Free Life; Gnotobiotic; Healing; Human subjects; Humans; Ileum - microbiology; Ileum - pathology; Inflammation; Inflammatory bowel diseases; Injuries; Interferon; Interferon Type I - metabolism; Intestinal microflora; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine; Macrophages; Macrophages - immunology; Macrophages - microbiology; Male; Meat; Meat products; Mice; Mice, Inbred C57BL; Microbiota; Mucosa; Prokaryotes; Ripening; Salinity tolerance; Symbiosis; Tissues; Ulcerative colitis; Wound healing; Wounds
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.abd0919

The gut microbiota includes not only prokaryotes, viruses, protists, and occasionally helminths, but also fungi. The role that fungi play in this symbiosis has long been overlooked. While investigating alterations to the gut microbiota in mice with mucosal damage and human subjects with Crohn's...