Development of novel polymer-stabilized diosmin nanosuspensions: In vitro appraisal and ex vivo permeation

• Published in: International journal of pharmaceutics Vol. 454; no. 1; pp. 462 - 471
• Main Authors: Freag, May S., Elnaggar, Yosra S.R., Abdallah, Ossama Y.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2013
• Subjects: absorption; Animals; Calorimetry, Differential Scanning; cellulose; Chemical Precipitation; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallization; Crystallography, X-Ray; differential scanning calorimetry; Diosmin; Diosmin - chemistry; Diosmin - metabolism; Dissolution; Drug Carriers; Drug Stability; drugs; Excipients - chemistry; high performance liquid chromatography; Hypromellose Derivatives; infrared spectroscopy; Intestinal Absorption; Intestines - metabolism; Kinetics; Male; mannitol; Methylcellulose - analogs & derivatives; Methylcellulose - chemistry; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocrystals; Nanoparticles; Nanosuspension; Nanotechnology; neutralization; Particle Size; Permeability; Permeation; Powder Diffraction; Rats; Rats, Wistar; scanning electron microscopy; Solubility; Spectroscopy, Fourier Transform Infrared; spray drying; Technology, Pharmaceutical - methods; transmission electron microscopes; transmission electron microscopy; X-radiation; X-ray diffraction; Nanocrystals; MC; Permeation; Nanosuspension; Dissolution; DSN; HPMC; Diosmin; methyl cellulose; hydroxypropylmethyl cellulose

Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanoprecipitation technique has been employed f...