Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 83; no. 5; pp. 386 - 396
• Main Authors: Arck, Petra C., Handjiski, Bori, Kuhlmei, Arne, Peters, Eva M. J., Knackstedt, Maike, Peter, Anita, Hunt, Stephen P., Klapp, Burghard F., Paus, Ralf
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.05.2005; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Dermatology; General aspects; Hair and nails disorders; Hair Follicle - growth & development; Mast Cells - metabolism; Mast Cells - pathology; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Neurokinin-1 - deficiency; Receptors, Neurokinin-1 - genetics; Receptors, Neurokinin-1 - metabolism; Stress, Physiological - genetics; Stress, Physiological - metabolism; Substance P - physiology; Up-Regulation; Hair; Skin disease; Growth; Stress; Hair (head); Medicine; Alopecia; Cell death; Animal; Knockout mouse; Inhibitor; Mast cell; Mast cells; Inhibition; Neurokinin-1 receptor; Hair loss; Apoptosis; Biological receptor

Despite the lack of insight on distinct mediators in the skin orchestrating the pathophysiological response to stress, hair loss has often been reported to be caused by stress. Recently we revealed the existence of a "brain-hair follicle axis" by characterizing the neurokinin (NK) substanc...