Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver

• Published in: Xenobiotica Vol. 49; no. 2; pp. 247 - 255
• Main Authors: Uno, Yasuhiro, Igawa, Yoshiyuki, Tanaka, Maori, Ohura, Kayoko, Hosokawa, Masakiyo, Imai, Teruko
• Format: Journal Article
• Language: English
• Published: England 01.02.2019
• Subjects: cynomolgus macaque; tissue expression; transcript variant; gene conversion; hydrolytic activity; Carboxylesterase

Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus macaques used widely in preclinical studies for drug metabolism. Three CES2 mRNAs were present in cynomolgus macaque liver. Th...