Validation of a multiplexed LC–MS/MS clinical assay to quantify insulin-like growth factor-binding proteins in human serum and its application in a clinical study - Liu, Nanjun; Tengstrand, Elizabeth; Boernsen, K. Olaf; Bek, Stephan; Hsieh, Frank (Toxicology and applied pharmacology, 2019)
Keywords: Alkylation reagent; Biomarkers - blood; Bulbo-Spinal Atrophy, X-Linked - blood; Bulbo-Spinal Atrophy, X-Linked - diagnosis; Calibration; Chromatography, Liquid - standards; Clinical Trials, Phase II as Topic; Humans; Insulin-Like Growth Factor Binding Proteins - blood; Insulin-like growth factor-binding proteins; LC–MS/MS; Male; Matrix effect; Predictive Value of Tests; Protein quantitation; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization - standards; Spinal and bulbar muscular atrophy; Tandem Mass Spectrometry - standards; Protein quantitation; Spinal and bulbar muscular atrophy; Matrix effect; Alkylation reagent; Insulin-like growth factor-binding proteins; LC–MS/MS