Mycobacterium avium grown in Acanthamoeba castellanii is protected from the effects of antimicrobials

• Published in: Antimicrobial agents and chemotherapy Vol. 44; no. 7; pp. 1990 - 1994
• Main Authors: MILTNER, E. C, BERMUDEZ, L. E
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2000
• Series: Note
• Subjects: Acanthamoeba - drug effects; Acanthamoeba - microbiology; Acanthamoeba - physiology; Acanthamoeba castellanii; AIDS/HIV; Animals; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Azithromycin - pharmacology; Bacteriology; Biological and medical sciences; Clarithromycin - pharmacology; Experimental Therapeutics; Fundamental and applied biological sciences. Psychology; HT29 Cells - drug effects; HT29 Cells - microbiology; Humans; Medical sciences; Mice; Microbial Sensitivity Tests; Microbiology; Mycobacterium avium; Mycobacterium avium - drug effects; Mycobacterium avium - growth & development; Mycobacterium avium - physiology; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Pharmacology. Drug treatments; Rifabutin - pharmacology; U937 Cells - drug effects; U937 Cells - microbiology; Clarithromycin; Lobosea; Azithromycin; Bacteria; Mechanism of action; Heterolobosea; Immunopathology; Protozoa; Mycobacterium avium; AIDS; Host; Acanthamoeba castellanii; Immune deficiency; In vitro; Macrolide; Biological activity; Infection; Rifabutin; Resistance; Sensitivity resistance; Mycobacteriales; Viral disease; Mycobacteriaceae; Actinomycetes; Antibacterial agent; Amoeba

Mycobacterium avium is a common cause of systemic bacterial infection in patients with AIDS. Infection with M. avium has been linked to bacterial colonization of domestic water supplies and commonly occurs through the gastrointestinal tract. Acanthamoeba castellanii, a waterborne protozoan, may serv...