Experimental evolution under different nutritional conditions changes the genomic architecture and virulence of Acinetobacter baumannii

• Published in: Communications biology Vol. 7; no. 1; pp. 1274 - 13
• Main Authors: Yun, Sohyeon, Min, Jihyeon, Han, Sunyong, Sim, Ho Seok, Kim, Se Kye, Lee, Jun Bong, Yoon, Jang Won, Yeom, Jinki, Park, Woojun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/21; 14/19; 14/34; 14/63; 38/22; 38/23; 38/39; 38/77; 38/90; 38/91; 631/326/22/1434; 631/326/41/2530; 631/326/421; Acinetobacter; Acinetobacter baumannii; Acinetobacter baumannii - genetics; Acinetobacter baumannii - pathogenicity; Acinetobacter Infections - microbiology; Animals; Antibiotics; Biomedical and Life Sciences; Chemokines; Drug Resistance, Multiple, Bacterial - genetics; Epithelial cells; Evolution; Evolution & development; Female; Genome, Bacterial; Genomic analysis; Genomics - methods; Humans; Immune system; Insertion sequences; Life Sciences; Mice; Multidrug resistance; Pathogens; Prophages; Translocation; Virulence; Virulence - genetics

This study uncovers the molecular processes governing the adaptive evolution of multidrug-resistant (MDR) pathogens without antibiotic pressure. Genomic analysis of MDR Acinetobacter baumannii cells cultured for 8000 generations under starvation conditions (EAB1) or nutrient-rich conditions (EAB2) r...