The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention

CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is upregulated in malignancies of the breast, lung, colorectum, ovary, kidney, liver, pancreas, and hematopoietic system. Here, we discuss CDCP1 as an important hub for oncogenic signaling and its key roles in malign...

Full description

Saved in:
Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 81; no. 9; pp. 2259 - 2269
Main Authors Khan, Tashbib, Kryza, Thomas, Lyons, Nicholas J, He, Yaowu, Hooper, John D
Format Journal Article
LanguageEnglish
Published United States 01.05.2021
Online AccessGet full text

Cover

Abstract CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is upregulated in malignancies of the breast, lung, colorectum, ovary, kidney, liver, pancreas, and hematopoietic system. Here, we discuss CDCP1 as an important hub for oncogenic signaling and its key roles in malignant transformation and summarize approaches focused on exploiting it for cancer diagnosis and therapy. Elevated levels of CDCP1 are associated with progressive disease and markedly poorer survival. Predominantly located on the cell surface, CDCP1 lies at the nexus of key tumorigenic and metastatic signaling cascades, including the SRC/PKCδ, PI3K/AKT, WNT, and RAS/ERK axes, the oxidative pentose phosphate pathway, and fatty acid oxidation, making important functional contributions to cancer cell survival and growth, metastasis, and treatment resistance. These findings have stimulated the development of agents that target CDCP1 for detection and treatment of a range of cancers, and results from preclinical models suggest that these approaches could be efficacious and have manageable toxicity profiles.
AbstractList CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is upregulated in malignancies of the breast, lung, colorectum, ovary, kidney, liver, pancreas, and hematopoietic system. Here, we discuss CDCP1 as an important hub for oncogenic signaling and its key roles in malignant transformation and summarize approaches focused on exploiting it for cancer diagnosis and therapy. Elevated levels of CDCP1 are associated with progressive disease and markedly poorer survival. Predominantly located on the cell surface, CDCP1 lies at the nexus of key tumorigenic and metastatic signaling cascades, including the SRC/PKCδ, PI3K/AKT, WNT, and RAS/ERK axes, the oxidative pentose phosphate pathway, and fatty acid oxidation, making important functional contributions to cancer cell survival and growth, metastasis, and treatment resistance. These findings have stimulated the development of agents that target CDCP1 for detection and treatment of a range of cancers, and results from preclinical models suggest that these approaches could be efficacious and have manageable toxicity profiles.
Author Khan, Tashbib
He, Yaowu
Kryza, Thomas
Lyons, Nicholas J
Hooper, John D
Author_xml – sequence: 1
  givenname: Tashbib
  surname: Khan
  fullname: Khan, Tashbib
  organization: Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
– sequence: 2
  givenname: Thomas
  orcidid: 0000-0003-1668-8551
  surname: Kryza
  fullname: Kryza, Thomas
  organization: Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
– sequence: 3
  givenname: Nicholas J
  surname: Lyons
  fullname: Lyons, Nicholas J
  organization: Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
– sequence: 4
  givenname: Yaowu
  surname: He
  fullname: He, Yaowu
  organization: Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia
– sequence: 5
  givenname: John D
  orcidid: 0000-0003-1054-8486
  surname: Hooper
  fullname: Hooper, John D
  email: john.hooper@mater.uq.edu.au
  organization: Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia. john.hooper@mater.uq.edu.au
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33509939$$D View this record in MEDLINE/PubMed
BookMark eNo9kF1LwzAUhoNM3If-BCWX3nTmo2lT70anbjBU2LwOaXI6K106k1bw37uyuavDy3nec-AZo4FrHCB0S8mUUiEfCCEyEnHKpka7iJGIZam8QCMquIzSOBYDNDozQzQO4esQBSXiCg05FyTLeDZC680n4Hyev1O8rrZO15Xb4kVXPOIZ3mi_hRaXjce5dgY8nkMLpq0ah7Wz-FD1eg9dWxm8dC34H3D98hpdlroOcHOaE_Tx_LTJF9Hq7WWZz1aRiRlro5ITnpXcgLEkLQQYIyxLMl0UMYgkNdaSzBpeMAMsEQkFy3hRyiQxTEApBJ-g--PdvW--Owit2lXBQF1rB00XFIsllzRJWY-KI2p8E4KHUu19tdP-V1Giep-qd6V6VyqfvSpGVO_z0Ls7veiKHdhz618g_wOdq3Kn
CitedBy_id crossref_primary_10_1007_s00262_023_03578_1
crossref_primary_10_1016_j_jbc_2022_102194
crossref_primary_10_7717_peerj_16023
crossref_primary_10_1158_1078_0432_CCR_22_1973
crossref_primary_10_3389_fvets_2023_1155804
crossref_primary_10_1016_j_jaut_2024_103228
crossref_primary_10_3389_fonc_2023_1142755
crossref_primary_10_1016_j_crphar_2021_100053
crossref_primary_10_1073_pnas_2317307121
crossref_primary_10_3390_cancers13236088
crossref_primary_10_3390_biom12020152
crossref_primary_10_1186_s10020_023_00761_z
crossref_primary_10_1016_j_cub_2022_06_038
crossref_primary_10_1016_j_jbc_2024_107347
crossref_primary_10_3390_ijms22126413
crossref_primary_10_1002_iub_2700
crossref_primary_10_1016_j_ebiom_2023_104623
crossref_primary_10_1016_j_isci_2023_106103
crossref_primary_10_1016_j_jbc_2023_104582
crossref_primary_10_1038_s41388_022_02327_5
crossref_primary_10_1371_journal_pone_0281873
crossref_primary_10_1038_s41589_021_00783_w
crossref_primary_10_1186_s13045_022_01384_3
crossref_primary_10_1038_s41598_022_26579_z
crossref_primary_10_3390_ijms23010146
crossref_primary_10_1161_CIRCRESAHA_123_323200
crossref_primary_10_3389_fgene_2022_1042540
crossref_primary_10_3389_fphar_2023_1192495
crossref_primary_10_1172_JCI157168
Cites_doi 10.1074/jbc.M309678200
10.1074/jbc.M111.335448
10.1158/1078-0432.CCR-08-2533
10.1634/stemcells.22-3-334
10.1038/s41388-018-0372-3
10.7150/thno.30736
10.1038/onc.2012.396
10.1038/sj.onc.1208582
10.1074/jbc.M109.096453
10.1038/s41418-020-0578-0
10.1111/cas.13218
10.1038/onc.2011.555
10.1016/j.jpba.2017.02.047
10.1038/s41388-018-0142-2
10.1038/s41388-019-0983-3
10.1038/bjc.2015.471
10.1002/iub.198
10.1111/j.1349-7006.2011.02052.x
10.1016/S0006-291X(03)01405-0
10.1074/mcp.M112.020115
10.1074/mcp.M111.012914
10.1158/1541-7786.MCR-09-0100
10.18632/oncotarget.11935
10.1016/j.yexcr.2013.12.019
10.1101/789339
10.1007/s00277-020-03907-9
10.1038/nrurol.2018.9
10.1007/s13277-015-3527-7
10.1053/j.gastro.2013.05.049
10.1038/onc.2015.101
10.1038/sj.onc.1206220
10.1038/nbt.1644
10.1016/j.ebiom.2019.05.044
10.1158/1541-7786.MCR-12-0544
10.1371/journal.pbio.3000425
10.1073/pnas.1703791114
10.1074/jbc.M111.227462
10.1158/1078-0432.CCR-20-0268
10.2353/ajpath.2008.070981
10.1016/S0002-9440(10)63568-7
10.1158/0008-5472.CAN-12-2496
10.1016/j.celrep.2015.03.044
10.1073/pnas.1222435110
10.1186/s12885-018-4500-9
10.1172/JCI131133
10.1016/j.molonc.2013.08.009
10.1182/blood-2010-10-313692
10.7150/thno.43589
10.1158/0008-5472.CAN-07-1657
10.2353/ajpath.2009.080890
10.7554/eLife.31098
10.1016/j.ebiom.2018.02.001
10.7150/thno.43539
10.1111/bju.15143
10.3390/ph13090245
10.1038/srep16426
10.1038/s41388-019-0755-0
10.1158/0008-5472.CAN-13-2995
10.18632/oncoscience.286
10.3390/md15090290
10.1158/0008-5472.CAN-10-0220
10.1038/onc.2012.547
10.1111/j.1349-7006.2008.01066.x
10.1186/s13058-016-0741-1
10.1073/pnas.1011777108
10.1158/1541-7786.MCR-13-0587
10.1245/s10434-014-3740-4
10.1038/onc.2011.246
10.1073/pnas.1704008114
10.18632/oncotarget.6193
10.1038/onc.2014.88
ContentType Journal Article
Copyright 2021 American Association for Cancer Research.
Copyright_xml – notice: 2021 American Association for Cancer Research.
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1158/0008-5472.can-20-2978
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList PubMed
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1538-7445
EndPage 2269
ExternalDocumentID 10_1158_0008_5472_CAN_20_2978
33509939
Genre Journal Article
Review
GroupedDBID ---
-ET
18M
29B
2WC
34G
39C
476
53G
5GY
5RE
5VS
6J9
ABOCM
ACGFO
ACIWK
ACPRK
ACSVP
ADBBV
ADCOW
ADNWM
AENEX
AFHIN
AFOSN
AFRAH
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
CS3
DIK
DU5
EBS
EJD
F5P
FRP
GX1
IH2
KQ8
L7B
LSO
NPM
OK1
P0W
P2P
PQQKQ
RCR
RHF
RHI
RNS
SJN
TR2
W2D
W8F
WH7
WOQ
YKV
YZZ
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c422t-f3039f3cecd07b5ecc5d269abb4e567cdd09dc3b2ce26561ed23bf866c25ef553
ISSN 0008-5472
IngestDate Fri Oct 25 22:13:56 EDT 2024
Thu Nov 21 22:17:16 EST 2024
Sat Sep 28 08:37:22 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
License 2021 American Association for Cancer Research.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c422t-f3039f3cecd07b5ecc5d269abb4e567cdd09dc3b2ce26561ed23bf866c25ef553
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0003-1668-8551
0000-0003-1054-8486
OpenAccessLink https://aacrjournals.org/cancerres/article-pdf/81/9/2259/3094450/2259.pdf
PMID 33509939
PQID 2483816725
PQPubID 23479
PageCount 11
ParticipantIDs proquest_miscellaneous_2483816725
crossref_primary_10_1158_0008_5472_CAN_20_2978
pubmed_primary_33509939
PublicationCentury 2000
PublicationDate 2021-05-01
PublicationDateYYYYMMDD 2021-05-01
PublicationDate_xml – month: 05
  year: 2021
  text: 2021-05-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Cancer research (Chicago, Ill.)
PublicationTitleAlternate Cancer Res
PublicationYear 2021
References Wortmann (2022061706390445800_bib41) 2011; 286
Yang (2022061706390445800_bib69) 2015; 6
Alajati (2022061706390445800_bib12) 2020; 130
Spassov (2022061706390445800_bib60) 2013; 73
Spassov (2022061706390445800_bib40) 2009; 174
Martinko (2022061706390445800_bib31) 2018; 7
Wright (2022061706390445800_bib21) 2017; 114
He (2022061706390445800_bib34) 2010; 285
Lin (2022061706390445800_bib35) 2014; 74
Hooper (2022061706390445800_bib37) 2003; 22
Gao (2022061706390445800_bib7) 2013; 145
Chiu (2022061706390445800_bib54) 2015; 5
Emerling (2022061706390445800_bib11) 2013; 110
Kryza (2022061706390445800_bib14) 2020; 10
Toth (2022061706390445800_bib47) 2003; 308
Gusenbauer (2022061706390445800_bib57) 2013; 32
Tang (2022061706390445800_bib65) 2010; 28
Cao (2022061706390445800_bib13) 2016; 37
Adams (2022061706390445800_bib26) 2015; 34
Mayor (2022061706390445800_bib67) 2020; 126
Shen (2022061706390445800_bib68) 2019; 44
Mamat (2022061706390445800_bib22) 2010; 23
Uekita (2022061706390445800_bib30) 2014; 12
Al-Awadhi (2022061706390445800_bib70) 2017; 15
He (2022061706390445800_bib9) 2016; 35
Kajiwara (2022061706390445800_bib48) 2019
Pollan (2022061706390445800_bib23) 2018; 37
Casar (2022061706390445800_bib39) 2014; 33
Miyazawa (2022061706390445800_bib46) 2013; 11
Harrington (2022061706390445800_bib49) 2020; 10
Sawada (2022061706390445800_bib62) 2014; 21
Harrington (2022061706390445800_bib8) 2016; 114
Sandvig (2022061706390445800_bib44) 2012; 11
Wortmann (2022061706390445800_bib1) 2009; 61
Lin (2022061706390445800_bib59) 2003; 163
Bhatt (2022061706390445800_bib36) 2005; 24
Chen (2022061706390445800_bib43) 2017; 139
Law (2022061706390445800_bib27) 2016; 18
Turdo (2022061706390445800_bib4) 2016; 7
He (2022061706390445800_bib3) 2016; 3
Razorenova (2022061706390445800_bib10) 2011; 108
Uekita (2022061706390445800_bib50) 2008; 172
Bühring (2022061706390445800_bib16) 2004; 22
Moroz (2022061706390445800_bib61) 2020; 26
Brown (2022061706390445800_bib33) 2004; 279
Karachaliou (2022061706390445800_bib55) 2018; 29
Enyindah-Asonye (2022061706390445800_bib42) 2017; 114
Boyer (2022061706390445800_bib58) 2013; 12
Alajati (2022061706390445800_bib5) 2015; 11
Yang (2022061706390445800_bib25) 2019; 38
Siva (2022061706390445800_bib63) 2008; 68
Miyazawa (2022061706390445800_bib15) 2010; 70
Joubert (2022061706390445800_bib66) 2020; 13
Gao (2022061706390445800_bib20) 2019; 17
Lin (2022061706390445800_bib45) 2020; 10
Cui (2022061706390445800_bib29) 2018; 37
Casar (2022061706390445800_bib38) 2012; 31
Gioia (2022061706390445800_bib56) 2011; 118
Dong (2022061706390445800_bib52) 2012; 287
Uekita (2022061706390445800_bib2) 2011; 102
Ikeda (2022061706390445800_bib6) 2009; 100
Nakashima (2022061706390445800_bib71) 2017; 108
Li (2022061706390445800_bib51) 2020; 27
Kollmorgen (2022061706390445800_bib72) 2013; 7
Jamaspishvili (2022061706390445800_bib32) 2018; 15
He (2022061706390445800_bib18) 2020; 39
Miura (2022061706390445800_bib19) 2014; 321
Deryugina (2022061706390445800_bib53) 2009; 7
Wong (2022061706390445800_bib64) 2009; 15
Heitmann (2022061706390445800_bib17) 2020; 99
Spassov (2022061706390445800_bib24) 2012; 31
Forte (2022061706390445800_bib28) 2018; 18
References_xml – volume: 279
  start-page: 14772
  year: 2004
  ident: 2022061706390445800_bib33
  article-title: Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M309678200
  contributor:
    fullname: Brown
– volume: 287
  start-page: 9792
  year: 2012
  ident: 2022061706390445800_bib52
  article-title: The cell surface glycoprotein CUB domain containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.335448
  contributor:
    fullname: Dong
– volume: 15
  start-page: 2311
  year: 2009
  ident: 2022061706390445800_bib64
  article-title: Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-08-2533
  contributor:
    fullname: Wong
– volume: 22
  start-page: 334
  year: 2004
  ident: 2022061706390445800_bib16
  article-title: CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin
  publication-title: Stem Cells
  doi: 10.1634/stemcells.22-3-334
  contributor:
    fullname: Bühring
– volume: 37
  start-page: 5794
  year: 2018
  ident: 2022061706390445800_bib29
  article-title: FBXL14 abolishes breast cancer progression by targeting CDCP1 for proteasomal degradation
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0372-3
  contributor:
    fullname: Cui
– volume: 10
  start-page: 2095
  year: 2020
  ident: 2022061706390445800_bib49
  article-title: Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer
  publication-title: Theranostics
  doi: 10.7150/thno.30736
  contributor:
    fullname: Harrington
– volume: 32
  start-page: 3846
  year: 2013
  ident: 2022061706390445800_bib57
  article-title: HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors
  publication-title: Oncogene
  doi: 10.1038/onc.2012.396
  contributor:
    fullname: Gusenbauer
– volume: 24
  start-page: 5333
  year: 2005
  ident: 2022061706390445800_bib36
  article-title: Adhesion signaling by a novel mitotic substrate of src kinases
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1208582
  contributor:
    fullname: Bhatt
– volume: 285
  start-page: 26162
  year: 2010
  ident: 2022061706390445800_bib34
  article-title: Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.096453
  contributor:
    fullname: He
– volume: 27
  start-page: 3289
  year: 2020
  ident: 2022061706390445800_bib51
  article-title: An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-020-0578-0
  contributor:
    fullname: Li
– volume: 108
  start-page: 1049
  year: 2017
  ident: 2022061706390445800_bib71
  article-title: Novel small molecule inhibiting CDCP1-PKCδ pathway reduces tumor metastasis and proliferation
  publication-title: Cancer Sci
  doi: 10.1111/cas.13218
  contributor:
    fullname: Nakashima
– volume: 31
  start-page: 3924
  year: 2012
  ident: 2022061706390445800_bib38
  article-title: Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells
  publication-title: Oncogene
  doi: 10.1038/onc.2011.555
  contributor:
    fullname: Casar
– volume: 139
  start-page: 65
  year: 2017
  ident: 2022061706390445800_bib43
  article-title: Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens
  publication-title: J Pharm Biomed
  doi: 10.1016/j.jpba.2017.02.047
  contributor:
    fullname: Chen
– volume: 37
  start-page: 2817
  year: 2018
  ident: 2022061706390445800_bib23
  article-title: Regulation of inside-out β1-integrin activation by CDCP1
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0142-2
  contributor:
    fullname: Pollan
– volume: 39
  start-page: 219
  year: 2020
  ident: 2022061706390445800_bib18
  article-title: CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0983-3
  contributor:
    fullname: He
– volume: 114
  start-page: 417
  year: 2016
  ident: 2022061706390445800_bib8
  article-title: Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2015.471
  contributor:
    fullname: Harrington
– volume: 61
  start-page: 723
  year: 2009
  ident: 2022061706390445800_bib1
  article-title: The cell surface glycoprotein CDCP1 in cancer- insights, opportunities, and challenges
  publication-title: IUBMB Life
  doi: 10.1002/iub.198
  contributor:
    fullname: Wortmann
– volume: 102
  start-page: 1943
  year: 2011
  ident: 2022061706390445800_bib2
  article-title: Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2011.02052.x
  contributor:
    fullname: Uekita
– volume: 308
  start-page: 386
  year: 2003
  ident: 2022061706390445800_bib47
  article-title: Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes
  publication-title: Biochem Biophy Res Comm
  doi: 10.1016/S0006-291X(03)01405-0
  contributor:
    fullname: Toth
– volume: 12
  start-page: 180
  year: 2013
  ident: 2022061706390445800_bib58
  article-title: Quantitative proteomics with siRNA screening identifies novel mechanisms of trastuzumab resistance in HER2 amplified breast cancers
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M112.020115
  contributor:
    fullname: Boyer
– volume: 11
  start-page: M111.012914
  year: 2012
  ident: 2022061706390445800_bib44
  article-title: Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M111.012914
  contributor:
    fullname: Sandvig
– volume: 7
  start-page: 1197
  year: 2009
  ident: 2022061706390445800_bib53
  article-title: Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-09-0100
  contributor:
    fullname: Deryugina
– volume: 7
  start-page: 69649
  year: 2016
  ident: 2022061706390445800_bib4
  article-title: CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.11935
  contributor:
    fullname: Turdo
– volume: 321
  start-page: 209
  year: 2014
  ident: 2022061706390445800_bib19
  article-title: CUB-domain containing protein 1 represses the epithelial phenotype of pancreatic cancer cells
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2013.12.019
  contributor:
    fullname: Miura
– volume-title: BioRxiv 789339 [Preprint]
  year: 2019
  ident: 2022061706390445800_bib48
  article-title: CUB domain-containing protein 1 controls HGF responses by integrating Src and Met–STAT3 signaling
  doi: 10.1101/789339
  contributor:
    fullname: Kajiwara
– volume: 99
  start-page: 477
  year: 2020
  ident: 2022061706390445800_bib17
  article-title: Identification of CD318 (CDCP1) as novel prognostic marker in AML
  publication-title: Ann Hematol
  doi: 10.1007/s00277-020-03907-9
  contributor:
    fullname: Heitmann
– volume: 15
  start-page: 222
  year: 2018
  ident: 2022061706390445800_bib32
  article-title: Clinical implications of PTEN loss in prostate cancer
  publication-title: Nat Rev Urol
  doi: 10.1038/nrurol.2018.9
  contributor:
    fullname: Jamaspishvili
– volume: 37
  start-page: 1651
  year: 2016
  ident: 2022061706390445800_bib13
  article-title: HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma
  publication-title: Tumor Biol
  doi: 10.1007/s13277-015-3527-7
  contributor:
    fullname: Cao
– volume: 145
  start-page: 636
  year: 2013
  ident: 2022061706390445800_bib7
  article-title: Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.05.049
  contributor:
    fullname: Gao
– volume: 35
  start-page: 468
  year: 2016
  ident: 2022061706390445800_bib9
  article-title: Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance
  publication-title: Oncogene
  doi: 10.1038/onc.2015.101
  contributor:
    fullname: He
– volume: 23
  start-page: 1221
  year: 2010
  ident: 2022061706390445800_bib22
  article-title: Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma
  publication-title: Oncol Rep
  contributor:
    fullname: Mamat
– volume: 22
  start-page: 1783
  year: 2003
  ident: 2022061706390445800_bib37
  article-title: Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206220
  contributor:
    fullname: Hooper
– volume: 28
  start-page: 749
  year: 2010
  ident: 2022061706390445800_bib65
  article-title: A mouse knockout library for secreted and transmembrane proteins
  publication-title: Nat Biotechnol
  doi: 10.1038/nbt.1644
  contributor:
    fullname: Tang
– volume: 44
  start-page: 322
  year: 2019
  ident: 2022061706390445800_bib68
  article-title: A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.05.044
  contributor:
    fullname: Shen
– volume: 11
  start-page: 628
  year: 2013
  ident: 2022061706390445800_bib46
  article-title: CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-12-0544
  contributor:
    fullname: Miyazawa
– volume: 17
  start-page: e3000425
  year: 2019
  ident: 2022061706390445800_bib20
  article-title: Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3000425
  contributor:
    fullname: Gao
– volume: 114
  start-page: E6556
  year: 2017
  ident: 2022061706390445800_bib21
  article-title: CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1703791114
  contributor:
    fullname: Wright
– volume: 286
  start-page: 42303
  year: 2011
  ident: 2022061706390445800_bib41
  article-title: Cellular settings mediating Src substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.227462
  contributor:
    fullname: Wortmann
– volume: 26
  start-page: 3608
  year: 2020
  ident: 2022061706390445800_bib61
  article-title: Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-20-0268
  contributor:
    fullname: Moroz
– volume: 172
  start-page: 1729
  year: 2008
  ident: 2022061706390445800_bib50
  article-title: CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma
  publication-title: Am J Pathol
  doi: 10.2353/ajpath.2008.070981
  contributor:
    fullname: Uekita
– volume: 163
  start-page: 2113
  year: 2003
  ident: 2022061706390445800_bib59
  article-title: Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)63568-7
  contributor:
    fullname: Lin
– volume: 73
  start-page: 1168
  year: 2013
  ident: 2022061706390445800_bib60
  article-title: Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-12-2496
  contributor:
    fullname: Spassov
– volume: 11
  start-page: 564
  year: 2015
  ident: 2022061706390445800_bib5
  article-title: Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2015.03.044
  contributor:
    fullname: Alajati
– volume: 110
  start-page: 3483
  year: 2013
  ident: 2022061706390445800_bib11
  article-title: Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1222435110
  contributor:
    fullname: Emerling
– volume: 18
  start-page: 586
  year: 2018
  ident: 2022061706390445800_bib28
  article-title: The PDGFRβ/ERK1/2 pathway regulates CDCP1 expression in triple-negative breast cancer
  publication-title: BMC Cancer
  doi: 10.1186/s12885-018-4500-9
  contributor:
    fullname: Forte
– volume: 130
  start-page: 2435
  year: 2020
  ident: 2022061706390445800_bib12
  article-title: CDCP1 overexpression drives prostate cancer progression and can be targeted in vivo
  publication-title: J Clin Invest
  doi: 10.1172/JCI131133
  contributor:
    fullname: Alajati
– volume: 7
  start-page: 1142
  year: 2013
  ident: 2022061706390445800_bib72
  article-title: Antibody mediated CDCP1 degradation as mode of action for cancer targeted therapy
  publication-title: Mol Oncol
  doi: 10.1016/j.molonc.2013.08.009
  contributor:
    fullname: Kollmorgen
– volume: 118
  start-page: 2211
  year: 2011
  ident: 2022061706390445800_bib56
  article-title: Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells
  publication-title: Blood
  doi: 10.1182/blood-2010-10-313692
  contributor:
    fullname: Gioia
– volume: 10
  start-page: 4116
  year: 2020
  ident: 2022061706390445800_bib14
  article-title: Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma
  publication-title: Theranostics
  doi: 10.7150/thno.43589
  contributor:
    fullname: Kryza
– volume: 68
  start-page: 3759
  year: 2008
  ident: 2022061706390445800_bib63
  article-title: Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-1657
  contributor:
    fullname: Siva
– volume: 174
  start-page: 1756
  year: 2009
  ident: 2022061706390445800_bib40
  article-title: The transmembrane src substrate Trask is an epithelial protein that signals during anchorage deprivation
  publication-title: The Am J Pathol
  doi: 10.2353/ajpath.2009.080890
  contributor:
    fullname: Spassov
– volume: 7
  start-page: e31098
  year: 2018
  ident: 2022061706390445800_bib31
  article-title: Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins
  publication-title: eLife
  doi: 10.7554/eLife.31098
  contributor:
    fullname: Martinko
– volume: 29
  start-page: 112
  year: 2018
  ident: 2022061706390445800_bib55
  article-title: Common co-activation of AXL and CDCP1 in EGFR-mutation-positive non-smallcell lung cancer associated with poor prognosis
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2018.02.001
  contributor:
    fullname: Karachaliou
– volume: 10
  start-page: 4871
  year: 2020
  ident: 2022061706390445800_bib45
  article-title: Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity
  publication-title: Theranostics
  doi: 10.7150/thno.43539
  contributor:
    fullname: Lin
– volume: 126
  start-page: 525
  year: 2020
  ident: 2022061706390445800_bib67
  article-title: Prostate-specific membrane antigen theranostics in advanced prostate cancer: an evolving option
  publication-title: BJU Int
  doi: 10.1111/bju.15143
  contributor:
    fullname: Mayor
– volume: 13
  start-page: 245
  year: 2020
  ident: 2022061706390445800_bib66
  article-title: Antibody–drug conjugates: the last decade
  publication-title: Pharmaceuticals
  doi: 10.3390/ph13090245
  contributor:
    fullname: Joubert
– volume: 5
  start-page: 16426
  year: 2015
  ident: 2022061706390445800_bib54
  article-title: ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis
  publication-title: Sci Rep
  doi: 10.1038/srep16426
  contributor:
    fullname: Chiu
– volume: 38
  start-page: 4755
  year: 2019
  ident: 2022061706390445800_bib25
  article-title: Dynamic m(6)A mRNA methylation reveals the role of METTL3-m(6)A-CDCP1 signaling axis in chemical carcinogenesis
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0755-0
  contributor:
    fullname: Yang
– volume: 74
  start-page: 5229
  year: 2014
  ident: 2022061706390445800_bib35
  article-title: ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-2995
  contributor:
    fullname: Lin
– volume: 3
  start-page: 5
  year: 2016
  ident: 2022061706390445800_bib3
  article-title: New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways
  publication-title: Oncoscience
  doi: 10.18632/oncoscience.286
  contributor:
    fullname: He
– volume: 15
  start-page: 290
  year: 2017
  ident: 2022061706390445800_bib70
  article-title: Kempopeptin C, a novel marine-derived serine protease inhibitor targeting invasive breast cancer
  publication-title: Marine Drugs
  doi: 10.3390/md15090290
  contributor:
    fullname: Al-Awadhi
– volume: 70
  start-page: 5136
  year: 2010
  ident: 2022061706390445800_bib15
  article-title: CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-0220
  contributor:
    fullname: Miyazawa
– volume: 33
  start-page: 255
  year: 2014
  ident: 2022061706390445800_bib39
  article-title: In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated beta1 integrin and induction of FAK/PI3K/Akt motility signaling
  publication-title: Oncogene
  doi: 10.1038/onc.2012.547
  contributor:
    fullname: Casar
– volume: 100
  start-page: 429
  year: 2009
  ident: 2022061706390445800_bib6
  article-title: Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2008.01066.x
  contributor:
    fullname: Ikeda
– volume: 18
  start-page: 80
  year: 2016
  ident: 2022061706390445800_bib27
  article-title: CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment
  publication-title: Breast Cancer Res
  doi: 10.1186/s13058-016-0741-1
  contributor:
    fullname: Law
– volume: 108
  start-page: 1931
  year: 2011
  ident: 2022061706390445800_bib10
  article-title: VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC δ -driven migration
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1011777108
  contributor:
    fullname: Razorenova
– volume: 12
  start-page: 1449
  year: 2014
  ident: 2022061706390445800_bib30
  article-title: Oncogenic Ras/ERK signaling activates CDCP1 to promote tumor invasion and metastasis
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-13-0587
  contributor:
    fullname: Uekita
– volume: 21
  start-page: 640
  year: 2014
  ident: 2022061706390445800_bib62
  article-title: Loss of CDCP1 expression promotes invasiveness and poor prognosis in esophageal squamous cell carcinoma
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-014-3740-4
  contributor:
    fullname: Sawada
– volume: 31
  start-page: 419
  year: 2012
  ident: 2022061706390445800_bib24
  article-title: A tumor-suppressing function in the epithelial adhesion protein Trask
  publication-title: Oncogene
  doi: 10.1038/onc.2011.246
  contributor:
    fullname: Spassov
– volume: 114
  start-page: E6912
  year: 2017
  ident: 2022061706390445800_bib42
  article-title: CD318 is a ligand for CD6
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1704008114
  contributor:
    fullname: Enyindah-Asonye
– volume: 6
  start-page: 43743
  year: 2015
  ident: 2022061706390445800_bib69
  article-title: Dysregulated expression of cell surface glycoprotein CDCP1 in prostate cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6193
  contributor:
    fullname: Yang
– volume: 34
  start-page: 1375
  year: 2015
  ident: 2022061706390445800_bib26
  article-title: EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface
  publication-title: Oncogene
  doi: 10.1038/onc.2014.88
  contributor:
    fullname: Adams
SSID ssj0005105
Score 2.5576756
SecondaryResourceType review_article
Snippet CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is upregulated in malignancies of the breast, lung, colorectum, ovary,...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
StartPage 2259
Title The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention
URI https://www.ncbi.nlm.nih.gov/pubmed/33509939
https://search.proquest.com/docview/2483816725
Volume 81
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZtCiGX0HeTPlCht6LtWpZkubfFTVgaElqygfRkLEvuBhJv2PUSkl_f0cOPpgm0vRgjYxn0fR5mpG9mEPqglUi01JxIFRsCpOBEqaggEGtoQZlmzLV7OzwS0xP29ZSf9if4LrukUaPy5s68kv9BFcYAV5sl-w_IdpPCANwDvnAFhOH61xhnX7Jv0cfjs5_Wo4awf7pWPtt85jTeTkaYWWiXYFsaEzqD19pqLdrMK78vGJSPQ3c1vBgqAs3dka_Xbjjbcn4-GuwkHMxDq-NiNVdnqhteXt8Ut7RIVgF0vfAuPHDRxter_oBq6jZZfxSLq_VwU4JGvQRwZHpDmjBfKrK1tL45S2BUOjSb1JcF_9Oec-kFkJJwllCI2WtgAKGp7_szwPjywoEcx-ABpb4-0q1C2u2jh-iRrZpoGy0cfO9Ly1tPM6R4wVc_3fnNLbTZzvK7H3NPcOKclNljtB2iCzzxVHmCHpj6Kdo8DPqJZ-gYQMeOMbhjDAbGfMYT7PmCgS_Yw447vmDgCx7wBQ_58hyd7O_NsikJbTVIyShtSAVeS1rFpSn1OFEc_mGuqUgLpZjhIim1Hqe6jBUtDQVvPzKaxqqSQpSUm4rz-AXaqBe1eYVwJTXYb2bgh44YLys5ToyQRgCeRVVUfAeN2kXKL331lNxFnVxa1YPM7QLn2eQop-PcLvAOet8uZQ52zh5eFbVZrFc5ZdKecScUJn3p17ibssVk994nr9FWT9M3aKNZrs1b8CYb9c6x4BdG-22B
link.rule.ids 314,780,784,27924,27925
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+CDCP1+Signaling+Hub%3A+A+Target+for+Cancer+Detection+and+Therapeutic+Intervention&rft.jtitle=Cancer+research+%28Chicago%2C+Ill.%29&rft.au=Khan%2C+Tashbib&rft.au=Kryza%2C+Thomas&rft.au=Lyons%2C+Nicholas+J&rft.au=He%2C+Yaowu&rft.date=2021-05-01&rft.eissn=1538-7445&rft.volume=81&rft.issue=9&rft.spage=2259&rft_id=info:doi/10.1158%2F0008-5472.can-20-2978&rft_id=info%3Apmid%2F33509939&rft.externalDocID=33509939
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0008-5472&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0008-5472&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0008-5472&client=summon