Recent advances in the analysis of flavonolignans of Silybum marianum
[Display omitted] •The chemistry of Silybum marianum flavonolignans was reviewed (23 compounds to date).•Methods of isolation and structure elucidation are discussed.•Analytical techniques, from spectrophotometry to LC–MS are presented.•The review is based on 124 references. Extracts of milk thistle...
Saved in:
| Published in | Journal of pharmaceutical and biomedical analysis Vol. 130; pp. 301 - 317 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
25.10.2016
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted]
•The chemistry of Silybum marianum flavonolignans was reviewed (23 compounds to date).•Methods of isolation and structure elucidation are discussed.•Analytical techniques, from spectrophotometry to LC–MS are presented.•The review is based on 124 references.
Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active constituents of milk thistle fruits are flavonolignans, collectively known as silymarin. Flavonolignans in S. marianum are structurally diverse, 23 constituents have been isolated from purple- and white-flowering variants. Flavonolignans have a broad spectrum of bioactivities and silymarin has been the subject of intensive research for its profound pharmacological activities. Silymarin is extracted from the seeds, commercialized in standardized form, and widely used in drugs and dietary supplements. The thorough analysis of silymarin, its constituents and silymarin-containing products has a key role in the quality control of milk thistle-based products. Due to the low concentration of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques.
The objective of the present review is to summarize the recent advances in the chemical analysis of S. marianum extracts, including the chemical composition, isolation and identification of flavonolignans, sample preparation, and methods used for qualitative and quantitative analysis. Various analytical approaches have been surveyed, and their respective advantages and limits are discussed. |
|---|---|
| AbstractList | [Display omitted]
•The chemistry of Silybum marianum flavonolignans was reviewed (23 compounds to date).•Methods of isolation and structure elucidation are discussed.•Analytical techniques, from spectrophotometry to LC–MS are presented.•The review is based on 124 references.
Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active constituents of milk thistle fruits are flavonolignans, collectively known as silymarin. Flavonolignans in S. marianum are structurally diverse, 23 constituents have been isolated from purple- and white-flowering variants. Flavonolignans have a broad spectrum of bioactivities and silymarin has been the subject of intensive research for its profound pharmacological activities. Silymarin is extracted from the seeds, commercialized in standardized form, and widely used in drugs and dietary supplements. The thorough analysis of silymarin, its constituents and silymarin-containing products has a key role in the quality control of milk thistle-based products. Due to the low concentration of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques.
The objective of the present review is to summarize the recent advances in the chemical analysis of S. marianum extracts, including the chemical composition, isolation and identification of flavonolignans, sample preparation, and methods used for qualitative and quantitative analysis. Various analytical approaches have been surveyed, and their respective advantages and limits are discussed. Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active constituents of milk thistle fruits are flavonolignans, collectively known as silymarin. Flavonolignans in S. marianum are structurally diverse, 23 constituents have been isolated from purple- and white-flowering variants. Flavonolignans have a broad spectrum of bioactivities and silymarin has been the subject of intensive research for its profound pharmacological activities. Silymarin is extracted from the seeds, commercialized in standardized form, and widely used in drugs and dietary supplements. The thorough analysis of silymarin, its constituents and silymarin-containing products has a key role in the quality control of milk thistle-based products. Due to the low concentration of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques. The objective of the present review is to summarize the recent advances in the chemical analysis of S. marianum extracts, including the chemical composition, isolation and identification of flavonolignans, sample preparation, and methods used for qualitative and quantitative analysis. Various analytical approaches have been surveyed, and their respective advantages and limits are discussed. Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active constituents of milk thistle fruits are flavonolignans, collectively known as silymarin. Flavonolignans in S. marianum are structurally diverse, 23 constituents have been isolated from purple- and white-flowering variants. Flavonolignans have a broad spectrum of bioactivities and silymarin has been the subject of intensive research for its profound pharmacological activities. Silymarin is extracted from the seeds, commercialized in standardized form, and widely used in drugs and dietary supplements. The thorough analysis of silymarin, its constituents and silymarin-containing products has a key role in the quality control of milk thistle-based products. Due to the low concentration of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques. The objective of the present review is to summarize the recent advances in the chemical analysis of S. marianum extracts, including the chemical composition, isolation and identification of flavonolignans, sample preparation, and methods used for qualitative and quantitative analysis. Various analytical approaches have been surveyed, and their respective advantages and limits are discussed.Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active constituents of milk thistle fruits are flavonolignans, collectively known as silymarin. Flavonolignans in S. marianum are structurally diverse, 23 constituents have been isolated from purple- and white-flowering variants. Flavonolignans have a broad spectrum of bioactivities and silymarin has been the subject of intensive research for its profound pharmacological activities. Silymarin is extracted from the seeds, commercialized in standardized form, and widely used in drugs and dietary supplements. The thorough analysis of silymarin, its constituents and silymarin-containing products has a key role in the quality control of milk thistle-based products. Due to the low concentration of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques. The objective of the present review is to summarize the recent advances in the chemical analysis of S. marianum extracts, including the chemical composition, isolation and identification of flavonolignans, sample preparation, and methods used for qualitative and quantitative analysis. Various analytical approaches have been surveyed, and their respective advantages and limits are discussed. |
| Author | Hohmann, Judit Csupor, Dezső Csorba, Attila |
| Author_xml | – sequence: 1 givenname: Dezső surname: Csupor fullname: Csupor, Dezső organization: Department of Pharmacognosy, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary – sequence: 2 givenname: Attila surname: Csorba fullname: Csorba, Attila organization: Department of Pharmacognosy, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary – sequence: 3 givenname: Judit surname: Hohmann fullname: Hohmann, Judit email: hohmann@pharm.u-szeged.hu organization: Department of Pharmacognosy, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27321822$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kE1LxDAQhoMo7vrxBzxIj15akzRtsuBFZP0AQfADvIVpOtUsbbI27cL-e7Oue_HgaYbhfYaZ54jsO--QkDNGM0ZZebnIFssKMh77jBYZzcUemTIl85SX4n2fTKnMWSqpKibkKIQFpbRgM3FIJlzmnCnOp2T-jAbdkEC9AmcwJNYlwycm4KBdBxsS3yRNCyvvfGs_HLifyYtt19XYJR30FtzYnZCDBtqAp7_1mLzdzl9v7tPHp7uHm-vH1AjOhxSRlyigBsElr0RRlbjpQcbLmoLViinTqJmsmRECYKaULGgZS0VnlWhofkwutnuXvf8aMQy6s8Fg24JDPwYdfyolFYKpGD3_jY5Vh7Ve9jZeu9a712NAbQOm9yH02GhjBxisd0MPttWM6o1lvdAby3pjWdNCR8sR5X_Q3fZ_oasthFHQymKvg7EYnde2RzPo2tv_8G9pp5UR |
| CitedBy_id | crossref_primary_10_3390_molecules26040791 crossref_primary_10_1016_j_jddst_2019_101181 crossref_primary_10_3390_foods9020116 crossref_primary_10_1080_23312009_2018_1477246 crossref_primary_10_1093_jpp_rgab159 crossref_primary_10_1155_2018_5329386 crossref_primary_10_3727_096504021X16218531628569 crossref_primary_10_2139_ssrn_4065738 crossref_primary_10_18311_jnr_2023_33662 crossref_primary_10_1002_slct_202200502 crossref_primary_10_3390_metabo13030440 crossref_primary_10_1016_j_indcrop_2021_114226 crossref_primary_10_3389_fpls_2021_733198 crossref_primary_10_3390_pharmaceutics16050618 crossref_primary_10_3389_fphar_2024_1417655 crossref_primary_10_3748_wjg_v23_i19_3388 crossref_primary_10_1080_14786419_2018_1499639 crossref_primary_10_1002_ardp_202400966 crossref_primary_10_1016_j_lwt_2022_113319 crossref_primary_10_1080_10942912_2023_2244685 crossref_primary_10_3390_pharmaceutics15071944 crossref_primary_10_1002_ptr_6470 crossref_primary_10_1080_00439339_2023_2234339 crossref_primary_10_3390_plants12122352 crossref_primary_10_3390_ijms22157885 crossref_primary_10_1016_j_jevs_2022_103937 crossref_primary_10_3390_nutraceuticals4020013 crossref_primary_10_1007_s00216_019_02274_3 crossref_primary_10_20307_nps_2018_24_2_82 crossref_primary_10_1007_s11694_018_0018_8 crossref_primary_10_1007_s11130_023_01101_6 crossref_primary_10_1002_elps_202100212 crossref_primary_10_1134_S2635167621020105 crossref_primary_10_3390_molecules24010061 crossref_primary_10_1002_pca_3478 crossref_primary_10_1016_j_biopha_2021_111970 crossref_primary_10_1186_s12906_023_04091_9 crossref_primary_10_1016_j_jep_2020_113303 crossref_primary_10_1002_sscp_202200161 crossref_primary_10_1186_s12906_024_04411_7 crossref_primary_10_1016_j_bmc_2022_116813 crossref_primary_10_1016_j_bmc_2021_116478 crossref_primary_10_2174_1871520620666200124112649 crossref_primary_10_1016_j_jcou_2023_102609 crossref_primary_10_1093_jaoacint_qsad105 crossref_primary_10_3390_ani11061687 crossref_primary_10_1021_acs_jafc_0c04791 crossref_primary_10_1016_j_bmc_2019_03_013 crossref_primary_10_1016_j_supflu_2018_03_011 crossref_primary_10_1093_jaoacint_qsaa110 crossref_primary_10_1016_j_foodres_2017_07_017 crossref_primary_10_1111_1541_4337_12629 crossref_primary_10_3390_catal11111390 crossref_primary_10_3390_molecules29132949 crossref_primary_10_2147_IJN_S407762 crossref_primary_10_3390_ani11010210 crossref_primary_10_1016_j_ejphar_2024_176906 crossref_primary_10_3390_molecules24010108 crossref_primary_10_2174_1871520623666230412111152 crossref_primary_10_3390_molecules22122080 crossref_primary_10_1016_j_acax_2020_100039 crossref_primary_10_1021_jasms_4c00125 crossref_primary_10_1093_plphys_kiab469 |
| Cites_doi | 10.1248/yakushi1947.95.8_1017 10.1016/j.phymed.2009.02.002 10.1093/chromsci/bmu049 10.3748/wjg.v17.i18.2288 10.1016/j.ijms.2012.02.021 10.1365/s10337-009-1127-7 10.1055/s-0029-1240624 10.1055/s-2007-971488 10.1023/A:1013706115045 10.1016/S0168-9452(99)00056-4 10.1002/cbdv.200490125 10.1016/j.jff.2015.02.031 10.1016/j.phymed.2012.09.004 10.1007/s00216-015-8925-6 10.1016/j.jchromb.2012.06.003 10.1002/bmc.1340 10.1053/j.gastro.2008.07.072 10.1006/phrs.2001.0854 10.3851/IMP2402 10.1016/S0021-9673(00)88397-1 10.1097/CAD.0000000000000211 10.1016/j.indcrop.2015.12.012 10.1016/j.molliq.2014.02.039 10.1016/S0367-326X(00)00134-9 10.1016/S0040-4039(01)96737-1 10.1016/j.chroma.2006.03.053 10.1002/rcm.3081 10.1016/S0168-8278(98)80285-7 10.1002/ptr.3207 10.1016/S0040-4039(01)83563-2 10.1093/chromsci/46.2.93 10.1177/1534735407301942 10.1055/s-2006-962330 10.1016/S0021-9673(02)01971-4 10.1016/j.chroma.2015.03.029 10.1556/AChrom.24.2012.3.9 10.1055/s-2007-969717 10.1111/j.1365-2893.2005.00636.x 10.1021/np3005369 10.2165/00003495-200161140-00003 10.1055/s-2005-864187 10.1002/ptr.2650070122 10.1515/znb-1971-0925 10.1002/pca.803 10.4103/0253-7613.36534 10.1039/c39790000696 10.1016/0168-8278(89)90083-4 10.1385/ABAB:108:1-3:881 10.1021/np030163b 10.1177/1534735407301825 10.1016/j.jchromb.2009.11.001 10.1080/01483919108049321 10.1016/j.talanta.2007.07.006 10.1016/j.jpba.2007.06.026 10.1055/s-2007-990239 10.1007/BF01309016 10.1007/s10337-011-2163-7 10.1097/01.mcg.0000165668.79530.a0 10.1016/S0731-7085(01)00364-8 10.1016/0959-8049(96)00011-1 10.1080/10826079308019612 10.1002/cber.19751080312 10.1016/S0021-9673(01)87884-5 10.1055/s-2007-981595 10.1385/ABAB:108:1-3:891 10.1073/pnas.0914009107 10.1111/jvim.12002 10.1016/S0731-7085(02)00352-7 10.1081/DDC-100000244 10.1016/j.jchromb.2007.10.040 10.1021/np400955q 10.1021/np070136b 10.1016/j.jpba.2005.01.021 10.1016/j.jchromb.2006.07.063 10.1021/jf063156c 10.1007/s11738-015-2008-3 10.1080/00032719.2014.924010 10.1002/rcm.1700 10.1016/S0021-9673(00)89876-3 10.1016/S0731-7085(98)00231-3 10.1007/BF02491573 10.1016/S0040-4039(00)89610-0 10.1039/b300099k 10.1016/j.jpba.2010.07.003 10.1124/dmd.107.017566 10.1016/j.talanta.2011.01.027 10.1039/C3NP70122K |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier B.V. Copyright © 2016 Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2016 Elsevier B.V. – notice: Copyright © 2016 Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.jpba.2016.05.034 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1873-264X |
| EndPage | 317 |
| ExternalDocumentID | 27321822 10_1016_j_jpba_2016_05_034 S0731708516302734 |
| Genre | Journal Article Review |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATCM AAXUO ABFRF ABJNI ABMAC ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADECG ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC C45 CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W KOM M34 M36 M41 MO0 N9A O-L O9- OAUVE OGGZJ OVD OZT P-8 P-9 P2P PC. Q38 RIG RNS ROL RPZ SCC SCH SDF SDG SDP SES SPC SPCBC SSK SSP SSZ T5K TEORI YK3 ~G- 29L 53G AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACNNM ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AHHHB AIGII AIIUN AJQLL AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HMT HMU HVGLF HZ~ R2- SCB SEW SPT SSH WUQ XPP CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c422t-ee26e4ada4272b45b6eda42a7000f51d818cf897d1c44aa9887506988b09b4f03 |
| IEDL.DBID | .~1 |
| ISSN | 0731-7085 1873-264X |
| IngestDate | Fri Jul 11 11:44:44 EDT 2025 Thu Apr 03 07:07:10 EDT 2025 Thu Apr 24 23:03:26 EDT 2025 Tue Jul 01 01:17:45 EDT 2025 Fri Feb 23 02:25:40 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | CC NP Chemical analysis Q-TOF Silybum marianum MRM TOF TLC Milk thistle IT Review VLC Silymarin LPLC Flavonolignans HPLC MPLC RP SQ |
| Language | English |
| License | Copyright © 2016 Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c422t-ee26e4ada4272b45b6eda42a7000f51d818cf897d1c44aa9887506988b09b4f03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 27321822 |
| PQID | 1826704418 |
| PQPubID | 23479 |
| PageCount | 17 |
| ParticipantIDs | proquest_miscellaneous_1826704418 pubmed_primary_27321822 crossref_citationtrail_10_1016_j_jpba_2016_05_034 crossref_primary_10_1016_j_jpba_2016_05_034 elsevier_sciencedirect_doi_10_1016_j_jpba_2016_05_034 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-10-25 |
| PublicationDateYYYYMMDD | 2016-10-25 |
| PublicationDate_xml | – month: 10 year: 2016 text: 2016-10-25 day: 25 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of pharmaceutical and biomedical analysis |
| PublicationTitleAlternate | J Pharm Biomed Anal |
| PublicationYear | 2016 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Polyak, Morishima, Lohmann, Pal, Lee, Liu, Graf, Oberlies (bib0005) 2010; 107 Bhattacharya (bib0110) 2011; 1 Saleh, Vinatoru, Mason, Abdel-Azim, Aboutabl, Hammouda (bib0420) 2015; 6 Vanhaelen, Vanhaelen-Fastre (bib0380) 1983; 281 Agarwal, Agarwal, Ichikawa, Singh, Aggarwal (bib0145) 2006; 26 Samu, Nyiredy, Baitz-Gacs, Varga, Kurtan, Dinya, Antus (bib0280) 2004; 1 Li, Han, Li, Li, hou, Liu (bib0555) 2008; 862 Arnone, Merlini, Zanarotti (bib0215) 1979 Rajasekaran (bib0340) 1997; 59 Reddy, Reddy, Murthy (bib0345) 2001; 13 Kaloga (bib0060) 1981; 36 Ding, Tian, Zhang, Gu, Chen, Shi, Sun (bib0585) 2001; 26 Scambia, De Vincenzo, Ranelletti, Panici, Ferrandina, D’Agostino, Fattorossi, Bombardelli, Mancuso (bib0010) 1996; 32A Barreto, Wallace, Carrier, Clausen (bib0540) 2003; 105 Biedermann, Vavrikova, Cvak, Kren (bib0075) 2014; 31 Saller, Brignoli, Melzer, Meier (bib0125) 2006; 15 Chiavari, Galletti, Marotti, Piccaglia (bib0330) 1991; 30 Liu, Du, Yuan (bib0510) 2009; 877 Quaglia, Bossù, Donati, Mazzanti, Brandt (bib0430) 1999; 19 Lee, Liu (bib0240) 2003; 66 Wallace, Carrier, Clausen (bib0405) 2005; 16 Kurkin, Zapesochnaya, Volotsueva, Avdeeva, Pimenov (bib0220) 2002; 37 Mericli (bib0285) 1988; 54 Graf, Wani, Agarwal, Kroll, Oberlies (bib0315) 2007; 73 Hadad, Emara, Abdel-Salam (bib0475) 2009; 70 Mascher, Kikuta, Weyhenmeyer (bib0500) 1993; 16 Wang, Zhang, Shen, Du, Li (bib0560) 2010; 53 Rambaldi, Jacobs, Gluud (bib0035) 2007 Wu, Lin, Hung, Chi, Tsai (bib0495) 2007; 45 Polyak, Oberlies, Pécheur, Dahari, Ferenci, Pawlotsky (bib0085) 2013; 18 Kshirsagar, Ingawale, Ashok, Vyawahare (bib0120) 2009; 3 Schindler (bib0170) 1952; 2 Ball, Kowdley (bib0155) 2005; 39 Katiyar (bib0165) 2005; 26 Campodonico, Collado, Ricci, Pappa, Segall, Pizzorno (bib0325) 2001; 27 El-Kamary, Shardell, Abdel-Hamid, Ismail, El-Ateek, Metwally, Mikhail, Hashem, Mousa, Aboul-Fotouh, El-Kassas, Esmat, Strickland (bib0030) 2009; 16 AbouZid, Chen, Pauli (bib0470) 2016; 83 Shakeel, Anwer, Shazly, Jamil (bib0395) 2014; 195 Lee, Hsu, Wu, Barrett (bib0545) 2006; 1116 Parés, Planas, Torres, Caballería, Viver, Acero, Panés, Rigau, Santos, Rodés (bib0025) 1998; 28 Kroll, Shaw, Oberlies (bib0130) 2007; 6 Sathish, Babu, Kumar, Pratap, Prasad (bib0350) 2005; 3 Begum, Sahai, Ray (bib0055) 2010; 93 Taha, Krawinkel, Morlock (bib0390) 2015; 1394 Kidd, Head (bib0160) 2005; 10 Alikaridis, Papadakis, Pantelia, Kephalas (bib0290) 2000; 71 Sy-Cordero, Graf, Nakanishi, Wani, Agarwal, Kroll, Oberlies (bib0260) 2010; 76 Kuki, Biri, Nagy, Deak, Kalmar, Mandi, Nagy, Zsuga, Kéki (bib0580) 2012; 315 Liu, Lee (bib0530) 2012; 4 Wagner, Seligmann, Hoerhammer, Seitz, Sonnenbichler (bib0195) 1971 Mayer, Myers, Lee (bib0150) 2005; 12 Martinelli, Morazzoni, Livio, Uberti (bib0490) 1991; 14 Calani, Brighenti, Bruni, Del Rio (bib0100) 2012; 20 Mastron, Siveen, Sethi, Bishayee (bib0070) 2015; 26 Mudge, Paley, Schieber, Brown (bib0415) 2015; 407 El-Elimat, Raja, Graf, Faeth, Cech, Oberlies (bib0300) 2014; 77 Ferenci, Scherzer, Kerschner, Rutter, Beinhardt, Hofer, Schöniger-Hekele, Holzmann, Steindl-Munda (bib0040) 2008; 135 Pelter, Haensel, Kaloga (bib0200) 1977 Mpanza, Sabela, Mathenjwa, Kanchi, Bisetty (bib0620) 2014; 47 Bilia, Bergonzi, Gallori, Mazzi, Vincieri (bib0455) 2002; 30 Omar, Hadad, Badr (bib0485) 2012; 24 Ding, Tian, Zhang, Shi, Sun (bib0605) 2000; 35 Rafieian-Kopaie, Nasri (bib0095) 2012; 1 Ahmad, Faiyazuddin, Hussain, Ahmad, Alshammari, Shakeel (bib0050) 2015; 37 Pelter, Hänsel (bib0190) 1975; 108 Wianowska, Wisniewski (bib0410) 2015; 53 Kéki, Tóth, Zsuga, Ferenczi, Antus (bib0595) 2007; 21 Wagner, Hoerhammer, Muenster (bib0175) 1968; 18 Galetti (bib0570) 1992; 20 Fiebig, Wagner (bib0275) 1984; 50 Wagner, Bladt (bib0360) 1996 Szilajtis-Obieglo, Kowalewska (bib0370) 1984; 30 Takemoto, Ikegawa, Nomoto (bib0205) 1975; 95 Bilia, Salvini, Mazzi, Vincieri (bib0450) 2000; 53 European Pharmacopoeia., Council Of Europe; European Directorate for the Quality of Medicines and Healthcare, Strasbourg, 2010. Wallace, Carrier, Clausen (bib0400) 2003; 105 Ferenci, Dragosics, Dittrich, Frank, Benda, Lochs, Meryn, Base, Schneider (bib0020) 1989; 9 Khan, Wu (bib0590) 2004; 18 Abenavoli, Capasso, Milic, Capasso (bib0115) 2010; 24 Cacho, Moran, Corchete, Fernandez-Tarrago (bib0295) 1999; 144 Cai, Li, Qiao, Lian, Wang (bib0425) 2009; 21 Martinez, Adzet, Iglesias (bib0525) 1991; 1 Sy-Cordero, Day, Oberlies (bib0320) 2012; 75 Tittel, Wagner (bib0435) 1977; 135 Skottova, Svagera, Vecera, Urbanek, Jegorov, Simanek (bib0515) 2001; 44 Pelter, Hänsel (bib0185) 1968; 9 Halbach, Winkler (bib0375) 1971; 26 Lee, Liu (bib0245) 2003 Lee, Narayan, Barrett (bib0550) 2007; 845 Smith, Lauren, Burgess, Perry, Martin (bib0250) 2005; 71 Kim, Graf, Sparacino, Wani, Wall (bib0225) 2003 Szilági, Tétényi, Antus, Seligmann, Chari, Seitz, Wagner (bib0270) 1981; 43 Hackett, Twedt, Gustafson (bib0080) 2012; 27 Hammouda, Ismail, Hassan, Zaki, Kamel, Rimpler (bib0445) 1993; 7 Zhao, Chen, Yao (bib0535) 2005; 38 Parveen, Ahmad, Baboota, Ali, Alka (bib0385) 2010; 24 Wen, Dumas, Schrieber, Hawke, Fried, Smith (bib0460) 2008; 36 Hassan, Khamis, El-Kimary, Barary (bib0610) 2008; 74 Zarapkar, Kanyawar, Rane (bib0335) 2000; 37 Hoh, Boocock, Marczylo, Brown, Cai, Steward, Berry, Gescher (bib0505) 2007; 55 Kuki, Nagy, Deak, Nagy, Zsuga, Keki (bib0575) 2012; 75 Loguercio, Festi (bib0105) 2011; 17 Shibano, Lin, Itokawa, Lee (bib0465) 2007; 70 MacKinnon, Hodder, Craft, Simmons-Boyce (bib0255) 2007; 73 Saller, Meier, Brignoli (bib0015) 2001; 61 Stieber, Szilágyi, Tétényi (bib0265) 1977; 16 Wagner, Seligmann, Seitz, Abraham, Sonnenbichler (bib0210) 1976; 31B Kim, Graf, Sparacino, Wani, Wall (bib0230) 2003; 1 Brinda, Zhu, Markowitz (bib0565) 2012; 902 Nyiredy, Samu, Szuecs, Gulacsi, Kurtan, Antus (bib0310) 2008; 46 Freudenberg, Neish (bib0305) 1968 Kvasnicka, Biba, Sevcik, Voldrich, Kratka (bib0600) 2003; 990 Martinez (bib0520) 1990; 47 Kim, Graf, Sparacino, Wani, Wall (bib0235) 2003; 1 Dixit, Baboota, Kohli, Ahmad, Ali (bib0135) 2007; 39 Wagner, Hörhammer, Seitz (bib0180) 1968; 18 Tittel, Wagner (bib0440) 1978; 153 Dashti-Khavidaki, Shahbazi, Khalili, Lessan-Pezeshki (bib0090) 2012; 15 Tamayo, Diamond (bib0140) 2007; 6 Marhol, Bednar, Kolarova, Vecera, Ulrichova, Tesarova, Vavríková, Kuzma, Kren (bib0480) 2015; 14 El-Desoky, Ghoneim (bib0615) 2011; 84 Surai (bib0065) 2015; 4 Wagner, Diesel, Seitz (bib0355) 1974; 24 Simova, Pangarova (bib0365) 1980; 30 Wu (10.1016/j.jpba.2016.05.034_bib0495) 2007; 45 Hassan (10.1016/j.jpba.2016.05.034_bib0610) 2008; 74 Kim (10.1016/j.jpba.2016.05.034_bib0225) 2003 Kim (10.1016/j.jpba.2016.05.034_bib0235) 2003; 1 Tamayo (10.1016/j.jpba.2016.05.034_bib0140) 2007; 6 El-Desoky (10.1016/j.jpba.2016.05.034_bib0615) 2011; 84 Sathish (10.1016/j.jpba.2016.05.034_bib0350) 2005; 3 Wagner (10.1016/j.jpba.2016.05.034_bib0195) 1971 Wagner (10.1016/j.jpba.2016.05.034_bib0360) 1996 Lee (10.1016/j.jpba.2016.05.034_bib0245) 2003 Lee (10.1016/j.jpba.2016.05.034_bib0545) 2006; 1116 Freudenberg (10.1016/j.jpba.2016.05.034_bib0305) 1968 Chiavari (10.1016/j.jpba.2016.05.034_bib0330) 1991; 30 Begum (10.1016/j.jpba.2016.05.034_bib0055) 2010; 93 Ferenci (10.1016/j.jpba.2016.05.034_bib0040) 2008; 135 Martinez (10.1016/j.jpba.2016.05.034_bib0520) 1990; 47 Saller (10.1016/j.jpba.2016.05.034_bib0125) 2006; 15 Reddy (10.1016/j.jpba.2016.05.034_bib0345) 2001; 13 Katiyar (10.1016/j.jpba.2016.05.034_bib0165) 2005; 26 Taha (10.1016/j.jpba.2016.05.034_bib0390) 2015; 1394 Marhol (10.1016/j.jpba.2016.05.034_bib0480) 2015; 14 Wagner (10.1016/j.jpba.2016.05.034_bib0210) 1976; 31B Kéki (10.1016/j.jpba.2016.05.034_bib0595) 2007; 21 Lee (10.1016/j.jpba.2016.05.034_bib0240) 2003; 66 Kaloga (10.1016/j.jpba.2016.05.034_bib0060) 1981; 36 Dixit (10.1016/j.jpba.2016.05.034_bib0135) 2007; 39 Loguercio (10.1016/j.jpba.2016.05.034_bib0105) 2011; 17 Bilia (10.1016/j.jpba.2016.05.034_bib0450) 2000; 53 Omar (10.1016/j.jpba.2016.05.034_bib0485) 2012; 24 Wen (10.1016/j.jpba.2016.05.034_bib0460) 2008; 36 Kroll (10.1016/j.jpba.2016.05.034_bib0130) 2007; 6 Sy-Cordero (10.1016/j.jpba.2016.05.034_bib0320) 2012; 75 Mericli (10.1016/j.jpba.2016.05.034_bib0285) 1988; 54 Kurkin (10.1016/j.jpba.2016.05.034_bib0220) 2002; 37 Khan (10.1016/j.jpba.2016.05.034_bib0590) 2004; 18 Wagner (10.1016/j.jpba.2016.05.034_bib0180) 1968; 18 Ding (10.1016/j.jpba.2016.05.034_bib0605) 2000; 35 Schindler (10.1016/j.jpba.2016.05.034_bib0170) 1952; 2 Zhao (10.1016/j.jpba.2016.05.034_bib0535) 2005; 38 Surai (10.1016/j.jpba.2016.05.034_bib0065) 2015; 4 Agarwal (10.1016/j.jpba.2016.05.034_bib0145) 2006; 26 Hackett (10.1016/j.jpba.2016.05.034_bib0080) 2012; 27 Kim (10.1016/j.jpba.2016.05.034_bib0230) 2003; 1 Martinez (10.1016/j.jpba.2016.05.034_bib0525) 1991; 1 Bilia (10.1016/j.jpba.2016.05.034_bib0455) 2002; 30 Rafieian-Kopaie (10.1016/j.jpba.2016.05.034_bib0095) 2012; 1 Mayer (10.1016/j.jpba.2016.05.034_bib0150) 2005; 12 Calani (10.1016/j.jpba.2016.05.034_bib0100) 2012; 20 Barreto (10.1016/j.jpba.2016.05.034_bib0540) 2003; 105 El-Elimat (10.1016/j.jpba.2016.05.034_bib0300) 2014; 77 Kvasnicka (10.1016/j.jpba.2016.05.034_bib0600) 2003; 990 Tittel (10.1016/j.jpba.2016.05.034_bib0440) 1978; 153 Smith (10.1016/j.jpba.2016.05.034_bib0250) 2005; 71 Saller (10.1016/j.jpba.2016.05.034_bib0015) 2001; 61 Abenavoli (10.1016/j.jpba.2016.05.034_bib0115) 2010; 24 Mudge (10.1016/j.jpba.2016.05.034_bib0415) 2015; 407 Alikaridis (10.1016/j.jpba.2016.05.034_bib0290) 2000; 71 Kuki (10.1016/j.jpba.2016.05.034_bib0575) 2012; 75 Arnone (10.1016/j.jpba.2016.05.034_bib0215) 1979 Pelter (10.1016/j.jpba.2016.05.034_bib0185) 1968; 9 Ball (10.1016/j.jpba.2016.05.034_bib0155) 2005; 39 Szilági (10.1016/j.jpba.2016.05.034_bib0270) 1981; 43 Wallace (10.1016/j.jpba.2016.05.034_bib0405) 2005; 16 Parés (10.1016/j.jpba.2016.05.034_bib0025) 1998; 28 MacKinnon (10.1016/j.jpba.2016.05.034_bib0255) 2007; 73 Scambia (10.1016/j.jpba.2016.05.034_bib0010) 1996; 32A Skottova (10.1016/j.jpba.2016.05.034_bib0515) 2001; 44 Mpanza (10.1016/j.jpba.2016.05.034_bib0620) 2014; 47 Simova (10.1016/j.jpba.2016.05.034_bib0365) 1980; 30 Polyak (10.1016/j.jpba.2016.05.034_bib0085) 2013; 18 Sy-Cordero (10.1016/j.jpba.2016.05.034_bib0260) 2010; 76 Zarapkar (10.1016/j.jpba.2016.05.034_bib0335) 2000; 37 Pelter (10.1016/j.jpba.2016.05.034_bib0200) 1977 Ding (10.1016/j.jpba.2016.05.034_bib0585) 2001; 26 Parveen (10.1016/j.jpba.2016.05.034_bib0385) 2010; 24 Cai (10.1016/j.jpba.2016.05.034_bib0425) 2009; 21 Lee (10.1016/j.jpba.2016.05.034_bib0550) 2007; 845 Kshirsagar (10.1016/j.jpba.2016.05.034_bib0120) 2009; 3 Szilajtis-Obieglo (10.1016/j.jpba.2016.05.034_bib0370) 1984; 30 Saleh (10.1016/j.jpba.2016.05.034_bib0420) 2015; 6 Brinda (10.1016/j.jpba.2016.05.034_bib0565) 2012; 902 Ahmad (10.1016/j.jpba.2016.05.034_bib0050) 2015; 37 Polyak (10.1016/j.jpba.2016.05.034_bib0005) 2010; 107 Pelter (10.1016/j.jpba.2016.05.034_bib0190) 1975; 108 Li (10.1016/j.jpba.2016.05.034_bib0555) 2008; 862 Mastron (10.1016/j.jpba.2016.05.034_bib0070) 2015; 26 Cacho (10.1016/j.jpba.2016.05.034_bib0295) 1999; 144 Wianowska (10.1016/j.jpba.2016.05.034_bib0410) 2015; 53 Hadad (10.1016/j.jpba.2016.05.034_bib0475) 2009; 70 Nyiredy (10.1016/j.jpba.2016.05.034_bib0310) 2008; 46 Halbach (10.1016/j.jpba.2016.05.034_bib0375) 1971; 26 Liu (10.1016/j.jpba.2016.05.034_bib0510) 2009; 877 Galetti (10.1016/j.jpba.2016.05.034_bib0570) 1992; 20 Wagner (10.1016/j.jpba.2016.05.034_bib0355) 1974; 24 Bhattacharya (10.1016/j.jpba.2016.05.034_bib0110) 2011; 1 Martinelli (10.1016/j.jpba.2016.05.034_bib0490) 1991; 14 Tittel (10.1016/j.jpba.2016.05.034_bib0435) 1977; 135 Ferenci (10.1016/j.jpba.2016.05.034_bib0020) 1989; 9 Takemoto (10.1016/j.jpba.2016.05.034_bib0205) 1975; 95 Wagner (10.1016/j.jpba.2016.05.034_bib0175) 1968; 18 AbouZid (10.1016/j.jpba.2016.05.034_bib0470) 2016; 83 Kuki (10.1016/j.jpba.2016.05.034_bib0580) 2012; 315 Wallace (10.1016/j.jpba.2016.05.034_bib0400) 2003; 105 Dashti-Khavidaki (10.1016/j.jpba.2016.05.034_bib0090) 2012; 15 Rajasekaran (10.1016/j.jpba.2016.05.034_bib0340) 1997; 59 Samu (10.1016/j.jpba.2016.05.034_bib0280) 2004; 1 Liu (10.1016/j.jpba.2016.05.034_bib0530) 2012; 4 Biedermann (10.1016/j.jpba.2016.05.034_bib0075) 2014; 31 Shibano (10.1016/j.jpba.2016.05.034_bib0465) 2007; 70 Vanhaelen (10.1016/j.jpba.2016.05.034_bib0380) 1983; 281 10.1016/j.jpba.2016.05.034_bib0045 Fiebig (10.1016/j.jpba.2016.05.034_bib0275) 1984; 50 Hoh (10.1016/j.jpba.2016.05.034_bib0505) 2007; 55 Shakeel (10.1016/j.jpba.2016.05.034_bib0395) 2014; 195 Kidd (10.1016/j.jpba.2016.05.034_bib0160) 2005; 10 Campodonico (10.1016/j.jpba.2016.05.034_bib0325) 2001; 27 Hammouda (10.1016/j.jpba.2016.05.034_bib0445) 1993; 7 Wang (10.1016/j.jpba.2016.05.034_bib0560) 2010; 53 Mascher (10.1016/j.jpba.2016.05.034_bib0500) 1993; 16 Quaglia (10.1016/j.jpba.2016.05.034_bib0430) 1999; 19 Stieber (10.1016/j.jpba.2016.05.034_bib0265) 1977; 16 Graf (10.1016/j.jpba.2016.05.034_bib0315) 2007; 73 Rambaldi (10.1016/j.jpba.2016.05.034_bib0035) 2007 El-Kamary (10.1016/j.jpba.2016.05.034_bib0030) 2009; 16 |
| References_xml | – reference: European Pharmacopoeia., Council Of Europe; European Directorate for the Quality of Medicines and Healthcare, Strasbourg, 2010. – volume: 9 start-page: 105 year: 1989 end-page: 113 ident: bib0020 article-title: Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver publication-title: J. Hepatol. – volume: 105 start-page: 891 year: 2003 end-page: 903 ident: bib0400 article-title: Extraction of nutraceuticals from milk thistle Part II. Extraction with organic solvents publication-title: Appl. Biochem. Biotechnol. – volume: 38 start-page: 564 year: 2005 end-page: 570 ident: bib0535 article-title: Simultaneous determination of abietane-type diterpenes, flavonolignans and phenolic compounds in compound preparations of publication-title: J. Pharm. Biomed. Anal. – volume: 30 start-page: 39 year: 1980 end-page: 42 ident: bib0365 article-title: Determination of silybin in raw materials and substances publication-title: Farmatsiya (Sofia) – year: 2003 ident: bib0225 article-title: Complete isolation and structure identification of hepatoprotective flavonolignans silybins and isosilybins from the medicinal herb milk thistle (Silybum marianum) publication-title: Abstr. Papers, 225th ACS National Meeting – volume: 12 start-page: 559 year: 2005 end-page: 567 ident: bib0150 article-title: Silymarin treatment of viral hepatitis: a systematic review publication-title: J. Viral Hepat. – volume: 26 start-page: 155 year: 2001 end-page: 161 ident: bib0585 article-title: Determination of active component in silymarin by RP-LC and LC/MS publication-title: J. Pharm. Biomed. Anal. – volume: 53 start-page: 1053 year: 2010 end-page: 1057 ident: bib0560 article-title: Rapid separation and characterization of active flavonolignans of publication-title: J. Pharm. Biomed. Anal. – volume: 3 start-page: 89 year: 2005 end-page: 93 ident: bib0350 article-title: New spectrophotometric methods for the estimation of Silymarin in pure and pharmaceutical dosage forms publication-title: Biosci. Biotechnol. Res. Asia – volume: 31 start-page: 1138 year: 2014 end-page: 1157 ident: bib0075 article-title: Chemistry of silybin publication-title: Nat. Prod. Rep. – volume: 61 start-page: 2035 year: 2001 end-page: 2063 ident: bib0015 article-title: The use of silymarin in the treatment of liver diseases publication-title: Drugs – volume: 53 start-page: 210 year: 2000 end-page: 215 ident: bib0450 article-title: Characterization of calendula flower, milk-thistle fruit, and passion flower tinctures by HPLC-DAD and HPLC-MS publication-title: Chromatographia – volume: 30 start-page: 27 year: 1984 end-page: 34 ident: bib0370 article-title: Spectrophotometric method for determination of flavonolignans and silybin in crude drugs and preparations from publication-title: Herba Pol. – volume: 44 start-page: 247 year: 2001 end-page: 253 ident: bib0515 article-title: Pharmacokinetic study of iodine-labeled silibinins in rat publication-title: Pharmacol. Res. – volume: 6 start-page: 709 year: 2015 end-page: 717 ident: bib0420 article-title: Ultrasonic-assisted extraction and conventional extraction of silymarin from publication-title: Res. J. Pharm. Biol. Chem. Sci. – start-page: CD003620 year: 2007 ident: bib0035 article-title: Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases publication-title: Cochrane Database Syst. Rev. – volume: 1 start-page: 3 year: 2012 end-page: 5 ident: bib0095 article-title: Silymarin and diabetic nephropathy publication-title: J. Ren. Inj. Prev. – volume: 16 start-page: 55 year: 1977 ident: bib0265 article-title: Hatóanyagtartalmi és összetételbeli különbségek a publication-title: Herba Hungarica – volume: 46 start-page: 93 year: 2008 end-page: 96 ident: bib0310 article-title: New insight into the biosynthesis of flavanolignans in the white-flowered variant of publication-title: J. Chromatogr. Sci. – volume: 73 start-page: 1495 year: 2007 end-page: 1501 ident: bib0315 article-title: Gram-scale purification of flavonolignan diastereoisomers from publication-title: Planta Med. – volume: 93 start-page: 1 year: 2010 end-page: 70 ident: bib0055 article-title: Non-conventional lignans: coumarinolignans, flavonolignans, and stilbenolignans publication-title: Prog. Chem. Org. Nat. Prod. – volume: 74 start-page: 773 year: 2008 end-page: 778 ident: bib0610 article-title: Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals publication-title: Talanta – start-page: 4547 year: 1977 end-page: 4548 ident: bib0200 article-title: The structure of silychristin publication-title: Tetrahedron Lett. – volume: 6 start-page: 110 year: 2007 end-page: 119 ident: bib0130 article-title: Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies publication-title: Integr. Cancer Ther. – volume: 20 start-page: 40 year: 2012 end-page: 46 ident: bib0100 article-title: Absorption and metabolism of milk thistle flavanolignans in humans publication-title: Phytomedicine – volume: 24 start-page: 639 year: 2010 end-page: 647 ident: bib0385 article-title: Stability-indicating HPTLC method for quantitative estimation of silybin in bulk drug and pharmaceutical dosage form publication-title: Biomed. Chromatogr. – start-page: 1895 year: 1971 end-page: 1899 ident: bib0195 article-title: Structure of silychristin, a second silymarin isomer from publication-title: Tetrahedron Lett. – volume: 862 start-page: 51 year: 2008 end-page: 57 ident: bib0555 article-title: Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. – volume: 1 start-page: 105 year: 1991 end-page: 114 ident: bib0525 article-title: Diffuse-reflectance Fourier transform-infrared spectroscopic microanalysis of the flavonolignans publication-title: Mikrochim. Acta – volume: 27 start-page: 261 year: 2001 end-page: 265 ident: bib0325 article-title: Dissolution test for silymarin tablets and capsules publication-title: Drug Dev. Ind. Pharm. – volume: 15 start-page: 9 year: 2006 end-page: 20 ident: bib0125 article-title: An updated systematic review with meta-analysis for the clinical evidence of silymarin publication-title: Forschen. Komplementärmedizin – volume: 18 start-page: 2960 year: 2004 end-page: 2962 ident: bib0590 article-title: Analysis of silymarin extracted from a commercial dosage by combining liquid–liquid extraction with negative electrospray tandem mass spectrometry publication-title: Rapid Commun. Mass Spectrom. – volume: 281 start-page: 263 year: 1983 end-page: 271 ident: bib0380 article-title: Quantitative determination of biologically active constituents in medicinal plant crude extracts by thin-layer chromatography-densitometry publication-title: J. Chromatogr. A. – volume: 37 start-page: 133 year: 2000 end-page: 134 ident: bib0335 article-title: Colorimetric estimation of silymarin in pharmaceutical dosage form publication-title: Indian Drugs. – volume: 153 start-page: 227 year: 1978 end-page: 232 ident: bib0440 article-title: High-performance liquid chromatography of silymarin. II. Quantitative determination of silymarin from publication-title: J. Chromatogr – volume: 26 start-page: 169 year: 2005 end-page: 176 ident: bib0165 article-title: Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (review) publication-title: Int. J. Oncol. – volume: 1394 start-page: 137 year: 2015 end-page: 147 ident: bib0390 article-title: High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry − a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts publication-title: J. Chromatogr. A. – volume: 70 start-page: 217 year: 2009 end-page: 221 ident: bib0475 article-title: Validated optimized method for simultaneous analysis of active silymarin components and dimethyl-4′-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in a pharmaceutical preparation by use of a monolithic silica publication-title: Chromatographia – volume: 15 start-page: 112 year: 2012 end-page: 123 ident: bib0090 article-title: Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature publication-title: J. Pharm. Pharm. Sci. a Publ. Can. Soc. Pharm. Sci. Société Can. Des Sci. Pharm. – year: 1968 ident: bib0305 article-title: Constitution and Biosynthesis of Lignin – volume: 3 start-page: 116 year: 2009 end-page: 124 ident: bib0120 article-title: Silymarin: a comprehensive review publication-title: Pharmacogn. Rev. – volume: 14 start-page: 1285 year: 1991 end-page: 1296 ident: bib0490 article-title: Liquid chromatographic assay of silybin in human plasma and urine publication-title: J. Liq. Chromatogr. – volume: 71 start-page: 877 year: 2005 end-page: 880 ident: bib0250 article-title: A silychristin isomer and variation of flavonolignan levels in milk thistle ( publication-title: Planta Med. – volume: 16 start-page: 2777 year: 1993 end-page: 2789 ident: bib0500 article-title: Diastereomeric separation of free and conjugated silibinin in plasma by reversed phase HPLC after specific extraction publication-title: J. Liq. Chromatogr. – volume: 20 start-page: 25 year: 1992 end-page: 31 ident: bib0570 article-title: Pyrolysis gas chromatography-mass spectrometry for the rapid analysis of phenolics in publication-title: Chim. Acta Turc. – volume: 877 start-page: 4159 year: 2009 end-page: 4163 ident: bib0510 article-title: A novel rapid method for simultaneous determination of eight active compounds in silymarin using a reversed-phase UPLC-UV detector publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. – volume: 43 start-page: 121 year: 1981 end-page: 127 ident: bib0270 article-title: Structure of silandrin and silymonin, two new flavanolignans from a white blooming publication-title: Planta Med. – volume: 18 start-page: 696 year: 1968 end-page: 698 ident: bib0180 article-title: Chemische Wertbestimmung eines Silymarin-haltigen Flavonoidkonzentrates aus publication-title: Arzneimittelforschung – volume: 47 start-page: 2813 year: 2014 end-page: 2828 ident: bib0620 article-title: Electrochemical determination of capsaicin and silymarin using a glassy carbon electrode modified by gold nanoparticle decorated multiwalledcarbon nanotubes publication-title: Anal. Lett. – volume: 95 start-page: 1017 year: 1975 end-page: 1021 ident: bib0205 article-title: Constituents of publication-title: Yakugaku Zasshi – volume: 37 start-page: 315 year: 2002 end-page: 317 ident: bib0220 article-title: Flavolignans of publication-title: Chem. Nat. Compd. – volume: 107 start-page: 5995 year: 2010 end-page: 5999 ident: bib0005 article-title: Identification of hepatoprotective flavonolignans from silymarin publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 30 start-page: 23 year: 1991 end-page: 34 ident: bib0330 article-title: Silymarin content of different publication-title: Herba Hung. – volume: 59 start-page: 230 year: 1997 ident: bib0340 article-title: Spectrophotometric determination of silymarin publication-title: Indian J. Pharm. Sci. – volume: 13 start-page: 1234 year: 2001 ident: bib0345 article-title: Spectrophotometric determination of silymarin publication-title: Asian J. Chem. – volume: 84 start-page: 223 year: 2011 end-page: 234 ident: bib0615 article-title: Stripping voltammetric determination of silymarin in formulations and human blood utilizing bare and modified carbon paste electrodes publication-title: Talanta – volume: 6 start-page: 146 year: 2007 end-page: 157 ident: bib0140 article-title: Review of clinical trials evaluating safety and efficacy of milk thistle ( publication-title: Integr. Cancer Ther. – volume: 36 start-page: 65 year: 2008 end-page: 72 ident: bib0460 article-title: Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract publication-title: Drug Metab. Dispos. – volume: 17 start-page: 2288 year: 2011 end-page: 2301 ident: bib0105 article-title: Silybin and the liver: from basic research to clinical practice publication-title: World J. Gastroenterol. – volume: 26 start-page: 4457 year: 2006 end-page: 4498 ident: bib0145 article-title: Anticancer potential of silymarin: from bench to bed side publication-title: Anticancer Res. – volume: 77 start-page: 193 year: 2014 end-page: 199 ident: bib0300 article-title: Flavonolignans from aspergillus iizukae, a fungal endophyte of milk thistle ( publication-title: J. Nat. Prod. – volume: 47 start-page: 162 year: 1990 end-page: 168 ident: bib0520 article-title: Supercritical fluid chromatography: a potentially useful technique for the analysis of flavonolignans publication-title: Ann. Pharm. Fr. – volume: 135 start-page: 1561 year: 2008 end-page: 1567 ident: bib0040 article-title: Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy publication-title: Gastroenterology – volume: 24 start-page: 1423 year: 2010 end-page: 1432 ident: bib0115 article-title: Milk thistle in liver diseases: past, present, future publication-title: Phyther. Res. – volume: 45 start-page: 635 year: 2007 end-page: 641 ident: bib0495 article-title: Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application publication-title: J. Pharm. Biomed. Anal. – volume: 195 start-page: 255 year: 2014 end-page: 258 ident: bib0395 article-title: Measurement and correlation of solubility of bioactive compound silymarin in five different green solvents at 298.15 publication-title: J. Mol. Liq. – start-page: 696 year: 1979 end-page: 697 ident: bib0215 article-title: Constituents of publication-title: J. Chem. Soc. Chem. Commun. – volume: 9 start-page: 2911 year: 1968 end-page: 2916 ident: bib0185 article-title: The structure of silybin ( publication-title: Tetrahedron Lett. – volume: 24 start-page: 463 year: 2012 end-page: 474 ident: bib0485 article-title: First detailed quantification of silymarin components in the leaves of publication-title: Acta Chromatogr. – volume: 71 start-page: 379 year: 2000 end-page: 384 ident: bib0290 article-title: Flavonolignan production from publication-title: Fitoterapia – volume: 4 start-page: 237 year: 2012 end-page: 244 ident: bib0530 article-title: Standardization and identification of minor components of silymarin (MK-001) publication-title: Chin. Herb. Med. – volume: 135 start-page: 499 year: 1977 end-page: 501 ident: bib0435 article-title: High-performance liquid chromatographic separation of silymarins and their determination in raw extracts of publication-title: J. Chromatogr – volume: 14 start-page: 570 year: 2015 end-page: 580 ident: bib0480 article-title: Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma publication-title: J. Funct. Foods – volume: 2 start-page: 291 year: 1952 end-page: 296 ident: bib0170 article-title: Active substances in pharmaceutical plants; methods to determine plant tinctures; contributions to a supplementary issue of the homoiopathic pharmacopeia publication-title: Arzneimittelforschung – volume: 50 start-page: 310 year: 1984 end-page: 313 ident: bib0275 article-title: New antihepatotoxically active flavonolignans from a white flowering variety of publication-title: Planta Med. – volume: 16 start-page: 7 year: 2005 end-page: 16 ident: bib0405 article-title: Batch solvent extraction of flavanolignans from milk thistle ( publication-title: Phytochem. Anal. – volume: 315 start-page: 46 year: 2012 end-page: 54 ident: bib0580 article-title: Collision induced dissociation study of the major components of silymarin publication-title: Int. J. Mass Spectrom. – volume: 73 start-page: 1214 year: 2007 end-page: 1216 ident: bib0255 article-title: Silyamandin, new flavonolignan isolated from milk thistle tinctures publication-title: Planta Med. – volume: 35 start-page: 778 year: 2000 end-page: 781 ident: bib0605 article-title: Separation and determination of effective components in silymarin and preparations of silymarin by MECC publication-title: Yaoxue Xuebao – volume: 7 start-page: 90 year: 1993 end-page: 91 ident: bib0445 article-title: Evaluation of the silymarin content in publication-title: Phyther. Res. – volume: 21 start-page: 2255 year: 2007 end-page: 2262 ident: bib0595 article-title: (+)-Silybin, a pharmacologically active constituent of publication-title: Rapid Commun. Mass Spectrom. – volume: 990 start-page: 239 year: 2003 end-page: 245 ident: bib0600 article-title: Analysis of the active components of silymarin publication-title: J. Chromatogr. A – volume: 4 start-page: 204 year: 2015 end-page: 247 ident: bib0065 article-title: Silymarin as a natural antioxidant: an overview of the current evidence and perspectives publication-title: Antioxidants (Basel, Switzerland) – volume: 75 start-page: 1879 year: 2012 end-page: 1881 ident: bib0320 article-title: Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-bromobenzoyl)isosilybin A publication-title: J. Nat. Prod. – volume: 16 start-page: 391 year: 2009 end-page: 400 ident: bib0030 article-title: A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis publication-title: Phytomedicine – volume: 845 start-page: 95 year: 2007 end-page: 103 ident: bib0550 article-title: Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. – volume: 54 start-page: 44 year: 1988 end-page: 45 ident: bib0285 article-title: Flavonolignans, kaempferol 3-sulfate and other flavonoids from publication-title: Planta Med. – volume: 105 start-page: 881 year: 2003 end-page: 889 ident: bib0540 article-title: Extraction of nutraceuticals from milk thistle I. Hot water extraction publication-title: Appl. Biochem. Biotechnol. – volume: 1 start-page: 69 year: 2011 end-page: 79 ident: bib0110 article-title: Phytotherapeutic properties of milk thistle seeds: an overview publication-title: J. Adv. Pharm. Educ. Res. – volume: 144 start-page: 63 year: 1999 end-page: 68 ident: bib0295 article-title: Influence of medium composition on the accumulation of flavonolignans in cultured cells of publication-title: Plant Sci. – volume: 39 start-page: 172 year: 2007 end-page: 179 ident: bib0135 article-title: Silymarin: a review of pharmacological aspects and bioavailability enhancement approaches publication-title: Indian J. Pharmacol. – volume: 32A start-page: 877 year: 1996 end-page: 882 ident: bib0010 article-title: Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin publication-title: Eur. J. Cancer – volume: 53 start-page: 366 year: 2015 end-page: 372 ident: bib0410 article-title: Simplified procedure of silymarin extraction from publication-title: J. Chromatogr. Sci. – volume: 24 start-page: 466 year: 1974 end-page: 471 ident: bib0355 article-title: Chemistry and analysis of silymarin from publication-title: Arzneim. −Forsch. – year: 1996 ident: bib0360 article-title: Plant Drug Analysis: A Thin Layer Chromatography Atlas – volume: 55 start-page: 2532 year: 2007 end-page: 2535 ident: bib0505 article-title: Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle ( publication-title: J. Agric. Food Chem. – volume: 39 start-page: 520 year: 2005 end-page: 528 ident: bib0155 article-title: A review of publication-title: J. Clin. Gastroenterol. – volume: 75 start-page: 175 year: 2012 end-page: 180 ident: bib0575 article-title: Identification of silymarin constituents: an improved HPLC-MS method publication-title: Chromatographia – volume: 28 start-page: 615 year: 1998 end-page: 621 ident: bib0025 article-title: Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial publication-title: J. Hepatol. – volume: 18 start-page: 688 year: 1968 end-page: 696 ident: bib0175 article-title: Chemistry of silymarin (silybin), the active component of the publication-title: Arzneim. − Forsch. – volume: 26 start-page: 971 year: 1971 end-page: 972 ident: bib0375 article-title: Flavonoids in fruits of the genus publication-title: Z. Naturforsch. B. – volume: 66 start-page: 1171 year: 2003 end-page: 1174 ident: bib0240 article-title: Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from publication-title: J. Nat. Prod. – volume: 70 start-page: 1424 year: 2007 end-page: 1428 ident: bib0465 article-title: Separation and characterization of active flavonolignans of publication-title: J. Nat. Prod. – volume: 26 start-page: 475 year: 2015 end-page: 486 ident: bib0070 article-title: Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review publication-title: Anticancer Drugs – volume: 27 start-page: 10 year: 2012 end-page: 16 ident: bib0080 article-title: Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease publication-title: J. Vet. Intern. Med. – volume: 1 start-page: 1684 year: 2003 end-page: 1689 ident: bib0230 article-title: Complete isolation and characterization of silybins and isosilybins from milk thistle ( publication-title: Org. Biomol. Chem. – volume: 1 start-page: 3470 year: 2003 ident: bib0235 article-title: Complete isolation and characterization of silybins and isosilybins from milk thistle ( publication-title: Org. Biomol. Chem. – volume: 37 year: 2015 ident: bib0050 article-title: Silymarin: an insight to its formulation and analytical prospects publication-title: Acta Physiol. Plant – volume: 18 start-page: 141 year: 2013 end-page: 147 ident: bib0085 article-title: Silymarin for HCV infection publication-title: Antivir. Ther. – volume: 31B start-page: 876 year: 1976 end-page: 884 ident: bib0210 article-title: Silydianin and silychristin, two isomeric silymarins from publication-title: Z. Naturforsch. B Anorg. Chem., Org. Chem. – volume: 407 start-page: 7657 year: 2015 end-page: 7666 ident: bib0415 article-title: Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection publication-title: Anal. Bioanal. Chem. – volume: 36 start-page: 262 year: 1981 end-page: 265 ident: bib0060 article-title: Isosilychristin, a new flavonolignan from publication-title: Sect. B-a J. Chem. Sci. – volume: 10 start-page: 193 year: 2005 end-page: 203 ident: bib0160 article-title: A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos) publication-title: Altern. Med. Rev. – volume: 76 start-page: 644 year: 2010 end-page: 647 ident: bib0260 article-title: Large-scale isolation of flavonolignans from publication-title: Planta Med. – volume: 19 start-page: 435 year: 1999 end-page: 442 ident: bib0430 article-title: Determination of silymarine in the extract from the dried publication-title: J. Pharm. Biomed. Anal. – volume: 30 start-page: 613 year: 2002 end-page: 624 ident: bib0455 article-title: Stability of the constituents of Calendula, Milk-thistle and Passionflower tinctures by LC-DAD and LC-MS publication-title: J. Pharm. Biomed. Anal. – volume: 1 start-page: 1668 year: 2004 end-page: 1677 ident: bib0280 article-title: Structure elucidation and antioxidant activity of (−)-isosilandrin isolated from publication-title: Chem. Biodivers. – volume: 83 start-page: 729 year: 2016 end-page: 737 ident: bib0470 article-title: Silymarin content in Silybum marianum populations growing in Egypt publication-title: Ind. Crop. Prod. – volume: 902 start-page: 1 year: 2012 end-page: 9 ident: bib0565 article-title: A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. – year: 2003 ident: bib0245 article-title: Three new flavonolignans isolated from the seeds of Silybum marianum publication-title: Abstr. Papers, 226th ACS National Meeting – volume: 108 start-page: 790 year: 1975 end-page: 802 ident: bib0190 article-title: Struktur des silybins: I. Abbauversuche publication-title: Chem. Ber. – volume: 1116 start-page: 57 year: 2006 end-page: 68 ident: bib0545 article-title: Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry publication-title: J. Chromatogr. A. – volume: 21 start-page: 63 year: 2009 end-page: 74 ident: bib0425 article-title: Determination of silymarin flavonoids by HPLC and LC-MS and investigation of extraction rate of silymarin in publication-title: Asian J. Chem. – volume: 3 start-page: 89 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0350 article-title: New spectrophotometric methods for the estimation of Silymarin in pure and pharmaceutical dosage forms publication-title: Biosci. Biotechnol. Res. Asia – volume: 1 start-page: 3 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0095 article-title: Silymarin and diabetic nephropathy publication-title: J. Ren. Inj. Prev. – volume: 95 start-page: 1017 year: 1975 ident: 10.1016/j.jpba.2016.05.034_bib0205 article-title: Constituents of Silybum marianum. I. New flavonolignans named 2,3-dehydrosilymarin and 2,3-dehydrosilychristin publication-title: Yakugaku Zasshi doi: 10.1248/yakushi1947.95.8_1017 – volume: 16 start-page: 391 year: 2009 ident: 10.1016/j.jpba.2016.05.034_bib0030 article-title: A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis publication-title: Phytomedicine doi: 10.1016/j.phymed.2009.02.002 – volume: 10 start-page: 193 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0160 article-title: A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos) publication-title: Altern. Med. Rev. – volume: 53 start-page: 366 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0410 article-title: Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner publication-title: J. Chromatogr. Sci. doi: 10.1093/chromsci/bmu049 – volume: 17 start-page: 2288 year: 2011 ident: 10.1016/j.jpba.2016.05.034_bib0105 article-title: Silybin and the liver: from basic research to clinical practice publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v17.i18.2288 – volume: 21 start-page: 63 year: 2009 ident: 10.1016/j.jpba.2016.05.034_bib0425 article-title: Determination of silymarin flavonoids by HPLC and LC-MS and investigation of extraction rate of silymarin in Silybum marianum fruits by boiling water publication-title: Asian J. Chem. – volume: 315 start-page: 46 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0580 article-title: Collision induced dissociation study of the major components of silymarin publication-title: Int. J. Mass Spectrom. doi: 10.1016/j.ijms.2012.02.021 – year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0245 article-title: Three new flavonolignans isolated from the seeds of Silybum marianum – volume: 70 start-page: 217 year: 2009 ident: 10.1016/j.jpba.2016.05.034_bib0475 article-title: Validated optimized method for simultaneous analysis of active silymarin components and dimethyl-4′-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate in a pharmaceutical preparation by use of a monolithic silica publication-title: Chromatographia doi: 10.1365/s10337-009-1127-7 – volume: 15 start-page: 112 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0090 article-title: Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature publication-title: J. Pharm. Pharm. Sci. a Publ. Can. Soc. Pharm. Sci. Société Can. Des Sci. Pharm. – volume: 16 start-page: 55 year: 1977 ident: 10.1016/j.jpba.2016.05.034_bib0265 article-title: Hatóanyagtartalmi és összetételbeli különbségek a Silybum genus két fajában (Silybum marianum (L.) Gaertn és Silybum eburneum coss. et durr.) publication-title: Herba Hungarica – volume: 47 start-page: 162 year: 1990 ident: 10.1016/j.jpba.2016.05.034_bib0520 article-title: Supercritical fluid chromatography: a potentially useful technique for the analysis of flavonolignans publication-title: Ann. Pharm. Fr. – volume: 76 start-page: 644 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0260 article-title: Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships publication-title: Planta Med. doi: 10.1055/s-0029-1240624 – volume: 43 start-page: 121 year: 1981 ident: 10.1016/j.jpba.2016.05.034_bib0270 article-title: Structure of silandrin and silymonin, two new flavanolignans from a white blooming Silybum marianum variety publication-title: Planta Med. doi: 10.1055/s-2007-971488 – volume: 37 start-page: 315 year: 2002 ident: 10.1016/j.jpba.2016.05.034_bib0220 article-title: Flavolignans of Silybum marianum fruit publication-title: Chem. Nat. Compd. doi: 10.1023/A:1013706115045 – volume: 144 start-page: 63 year: 1999 ident: 10.1016/j.jpba.2016.05.034_bib0295 article-title: Influence of medium composition on the accumulation of flavonolignans in cultured cells of Silybum marianum (L.) Gaertn publication-title: Plant Sci. doi: 10.1016/S0168-9452(99)00056-4 – volume: 1 start-page: 1668 year: 2004 ident: 10.1016/j.jpba.2016.05.034_bib0280 article-title: Structure elucidation and antioxidant activity of (−)-isosilandrin isolated from Silybum marianum L publication-title: Chem. Biodivers. doi: 10.1002/cbdv.200490125 – volume: 14 start-page: 570 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0480 article-title: Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma publication-title: J. Funct. Foods doi: 10.1016/j.jff.2015.02.031 – volume: 20 start-page: 40 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0100 article-title: Absorption and metabolism of milk thistle flavanolignans in humans publication-title: Phytomedicine doi: 10.1016/j.phymed.2012.09.004 – volume: 407 start-page: 7657 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0415 article-title: Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-015-8925-6 – volume: 902 start-page: 1 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0565 article-title: A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2012.06.003 – volume: 24 start-page: 639 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0385 article-title: Stability-indicating HPTLC method for quantitative estimation of silybin in bulk drug and pharmaceutical dosage form publication-title: Biomed. Chromatogr. doi: 10.1002/bmc.1340 – volume: 135 start-page: 1561 year: 2008 ident: 10.1016/j.jpba.2016.05.034_bib0040 article-title: Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.07.072 – volume: 44 start-page: 247 year: 2001 ident: 10.1016/j.jpba.2016.05.034_bib0515 article-title: Pharmacokinetic study of iodine-labeled silibinins in rat publication-title: Pharmacol. Res. doi: 10.1006/phrs.2001.0854 – volume: 18 start-page: 141 year: 2013 ident: 10.1016/j.jpba.2016.05.034_bib0085 article-title: Silymarin for HCV infection publication-title: Antivir. Ther. doi: 10.3851/IMP2402 – volume: 1 start-page: 69 year: 2011 ident: 10.1016/j.jpba.2016.05.034_bib0110 article-title: Phytotherapeutic properties of milk thistle seeds: an overview publication-title: J. Adv. Pharm. Educ. Res. – volume: 135 start-page: 499 year: 1977 ident: 10.1016/j.jpba.2016.05.034_bib0435 article-title: High-performance liquid chromatographic separation of silymarins and their determination in raw extracts of Silybum marianum Gaertn publication-title: J. Chromatogr doi: 10.1016/S0021-9673(00)88397-1 – volume: 26 start-page: 475 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0070 article-title: Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review publication-title: Anticancer Drugs doi: 10.1097/CAD.0000000000000211 – volume: 30 start-page: 23 year: 1991 ident: 10.1016/j.jpba.2016.05.034_bib0330 article-title: Silymarin content of different Silybum marianum L. Gaertn. cultivars publication-title: Herba Hung. – volume: 26 start-page: 169 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0165 article-title: Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (review) publication-title: Int. J. Oncol. – volume: 83 start-page: 729 year: 2016 ident: 10.1016/j.jpba.2016.05.034_bib0470 article-title: Silymarin content in Silybum marianum populations growing in Egypt publication-title: Ind. Crop. Prod. doi: 10.1016/j.indcrop.2015.12.012 – volume: 195 start-page: 255 year: 2014 ident: 10.1016/j.jpba.2016.05.034_bib0395 article-title: Measurement and correlation of solubility of bioactive compound silymarin in five different green solvents at 298.15K to 333.15K publication-title: J. Mol. Liq. doi: 10.1016/j.molliq.2014.02.039 – volume: 4 start-page: 237 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0530 article-title: Standardization and identification of minor components of silymarin (MK-001) publication-title: Chin. Herb. Med. – volume: 2 start-page: 291 year: 1952 ident: 10.1016/j.jpba.2016.05.034_bib0170 article-title: Active substances in pharmaceutical plants; methods to determine plant tinctures; contributions to a supplementary issue of the homoiopathic pharmacopeia publication-title: Arzneimittelforschung – volume: 71 start-page: 379 year: 2000 ident: 10.1016/j.jpba.2016.05.034_bib0290 article-title: Flavonolignan production from Silybum marianum transformed and untransformed root cultures publication-title: Fitoterapia doi: 10.1016/S0367-326X(00)00134-9 – ident: 10.1016/j.jpba.2016.05.034_bib0045 – start-page: 1895 year: 1971 ident: 10.1016/j.jpba.2016.05.034_bib0195 article-title: Structure of silychristin, a second silymarin isomer from Silybum marianum publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)96737-1 – volume: 1116 start-page: 57 year: 2006 ident: 10.1016/j.jpba.2016.05.034_bib0545 article-title: Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry publication-title: J. Chromatogr. A. doi: 10.1016/j.chroma.2006.03.053 – volume: 21 start-page: 2255 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0595 article-title: (+)-Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time-of-flight tandem mass spectrometry publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.3081 – volume: 28 start-page: 615 year: 1998 ident: 10.1016/j.jpba.2016.05.034_bib0025 article-title: Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial publication-title: J. Hepatol. doi: 10.1016/S0168-8278(98)80285-7 – volume: 24 start-page: 1423 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0115 article-title: Milk thistle in liver diseases: past, present, future publication-title: Phyther. Res. doi: 10.1002/ptr.3207 – start-page: 4547 year: 1977 ident: 10.1016/j.jpba.2016.05.034_bib0200 article-title: The structure of silychristin publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)83563-2 – volume: 46 start-page: 93 year: 2008 ident: 10.1016/j.jpba.2016.05.034_bib0310 article-title: New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum publication-title: J. Chromatogr. Sci. doi: 10.1093/chromsci/46.2.93 – volume: 6 start-page: 146 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0140 article-title: Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum[L.] Gaertn.) publication-title: Integr. Cancer Ther. doi: 10.1177/1534735407301942 – volume: 36 start-page: 262 year: 1981 ident: 10.1016/j.jpba.2016.05.034_bib0060 article-title: Isosilychristin, a new flavonolignan from Silybum marianum L. Gaertn., Zeitschrift für Naturforsch publication-title: Sect. B-a J. Chem. Sci. – volume: 54 start-page: 44 year: 1988 ident: 10.1016/j.jpba.2016.05.034_bib0285 article-title: Flavonolignans, kaempferol 3-sulfate and other flavonoids from Silybum marianum subsp anatolicum publication-title: Planta Med. doi: 10.1055/s-2006-962330 – volume: 990 start-page: 239 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0600 article-title: Analysis of the active components of silymarin publication-title: J. Chromatogr. A doi: 10.1016/S0021-9673(02)01971-4 – volume: 35 start-page: 778 year: 2000 ident: 10.1016/j.jpba.2016.05.034_bib0605 article-title: Separation and determination of effective components in silymarin and preparations of silymarin by MECC publication-title: Yaoxue Xuebao – volume: 1394 start-page: 137 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0390 article-title: High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry − a suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts publication-title: J. Chromatogr. A. doi: 10.1016/j.chroma.2015.03.029 – volume: 24 start-page: 463 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0485 article-title: First detailed quantification of silymarin components in the leaves of Silybum marianum cultivated in Egypt during different growth stages publication-title: Acta Chromatogr. doi: 10.1556/AChrom.24.2012.3.9 – volume: 93 start-page: 1 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0055 article-title: Non-conventional lignans: coumarinolignans, flavonolignans, and stilbenolignans publication-title: Prog. Chem. Org. Nat. Prod. – volume: 50 start-page: 310 year: 1984 ident: 10.1016/j.jpba.2016.05.034_bib0275 article-title: New antihepatotoxically active flavonolignans from a white flowering variety of Silybum publication-title: Planta Med. doi: 10.1055/s-2007-969717 – volume: 12 start-page: 559 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0150 article-title: Silymarin treatment of viral hepatitis: a systematic review publication-title: J. Viral Hepat. doi: 10.1111/j.1365-2893.2005.00636.x – volume: 75 start-page: 1879 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0320 article-title: Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-bromobenzoyl)isosilybin A publication-title: J. Nat. Prod. doi: 10.1021/np3005369 – volume: 61 start-page: 2035 year: 2001 ident: 10.1016/j.jpba.2016.05.034_bib0015 article-title: The use of silymarin in the treatment of liver diseases publication-title: Drugs doi: 10.2165/00003495-200161140-00003 – volume: 71 start-page: 877 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0250 article-title: A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits publication-title: Planta Med. doi: 10.1055/s-2005-864187 – volume: 7 start-page: 90 year: 1993 ident: 10.1016/j.jpba.2016.05.034_bib0445 article-title: Evaluation of the silymarin content in Silybum marianum (L.) Gaertn. cultivated under different agrcultural conditions publication-title: Phyther. Res. doi: 10.1002/ptr.2650070122 – volume: 26 start-page: 971 year: 1971 ident: 10.1016/j.jpba.2016.05.034_bib0375 article-title: Flavonoids in fruits of the genus Silybum eburneum publication-title: Z. Naturforsch. B. doi: 10.1515/znb-1971-0925 – volume: 6 start-page: 709 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0420 article-title: Ultrasonic-assisted extraction and conventional extraction of silymarin from Silybum marianum seeds; a comparison publication-title: Res. J. Pharm. Biol. Chem. Sci. – volume: 30 start-page: 27 year: 1984 ident: 10.1016/j.jpba.2016.05.034_bib0370 article-title: Spectrophotometric method for determination of flavonolignans and silybin in crude drugs and preparations from Silybum marianum L. (Gaertn.) publication-title: Herba Pol. – volume: 16 start-page: 7 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0405 article-title: Batch solvent extraction of flavanolignans from milk thistle (Silybum marianum L. gaertner) publication-title: Phytochem. Anal. doi: 10.1002/pca.803 – volume: 39 start-page: 172 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0135 article-title: Silymarin: a review of pharmacological aspects and bioavailability enhancement approaches publication-title: Indian J. Pharmacol. doi: 10.4103/0253-7613.36534 – start-page: 696 year: 1979 ident: 10.1016/j.jpba.2016.05.034_bib0215 article-title: Constituents of Silybum marianum. Structure of isosilybin and stereochemistry of silybin publication-title: J. Chem. Soc. Chem. Commun. doi: 10.1039/c39790000696 – volume: 3 start-page: 116 year: 2009 ident: 10.1016/j.jpba.2016.05.034_bib0120 article-title: Silymarin: a comprehensive review publication-title: Pharmacogn. Rev. – volume: 9 start-page: 105 year: 1989 ident: 10.1016/j.jpba.2016.05.034_bib0020 article-title: Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver publication-title: J. Hepatol. doi: 10.1016/0168-8278(89)90083-4 – volume: 105 start-page: 881 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0540 article-title: Extraction of nutraceuticals from milk thistle I. Hot water extraction publication-title: Appl. Biochem. Biotechnol. doi: 10.1385/ABAB:108:1-3:881 – volume: 18 start-page: 696 year: 1968 ident: 10.1016/j.jpba.2016.05.034_bib0180 article-title: Chemische Wertbestimmung eines Silymarin-haltigen Flavonoidkonzentrates aus Silybum marianum (L.) Gaertn publication-title: Arzneimittelforschung – volume: 66 start-page: 1171 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0240 article-title: Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from Silybum marianum (milk thistle) publication-title: J. Nat. Prod. doi: 10.1021/np030163b – volume: 6 start-page: 110 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0130 article-title: Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies publication-title: Integr. Cancer Ther. doi: 10.1177/1534735407301825 – volume: 877 start-page: 4159 year: 2009 ident: 10.1016/j.jpba.2016.05.034_bib0510 article-title: A novel rapid method for simultaneous determination of eight active compounds in silymarin using a reversed-phase UPLC-UV detector publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2009.11.001 – volume: 14 start-page: 1285 year: 1991 ident: 10.1016/j.jpba.2016.05.034_bib0490 article-title: Liquid chromatographic assay of silybin in human plasma and urine publication-title: J. Liq. Chromatogr. doi: 10.1080/01483919108049321 – volume: 74 start-page: 773 year: 2008 ident: 10.1016/j.jpba.2016.05.034_bib0610 article-title: Development of a differential pulse voltammetric method for the determination of Silymarin/Vitamin E acetate mixture in pharmaceuticals publication-title: Talanta doi: 10.1016/j.talanta.2007.07.006 – year: 1968 ident: 10.1016/j.jpba.2016.05.034_bib0305 – start-page: CD003620 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0035 article-title: Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases publication-title: Cochrane Database Syst. Rev. – volume: 26 start-page: 4457 year: 2006 ident: 10.1016/j.jpba.2016.05.034_bib0145 article-title: Anticancer potential of silymarin: from bench to bed side publication-title: Anticancer Res. – volume: 1 start-page: 3470 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0235 article-title: Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum). [Erratum to document cited in CA139:242961] publication-title: Org. Biomol. Chem. – volume: 45 start-page: 635 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0495 article-title: Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2007.06.026 – volume: 73 start-page: 1495 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0315 article-title: Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (milk thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention publication-title: Planta Med. doi: 10.1055/s-2007-990239 – volume: 1 start-page: 105 year: 1991 ident: 10.1016/j.jpba.2016.05.034_bib0525 article-title: Diffuse-reflectance Fourier transform-infrared spectroscopic microanalysis of the flavonolignans publication-title: Mikrochim. Acta doi: 10.1007/BF01309016 – volume: 75 start-page: 175 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0575 article-title: Identification of silymarin constituents: an improved HPLC-MS method publication-title: Chromatographia doi: 10.1007/s10337-011-2163-7 – year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0225 article-title: Complete isolation and structure identification of hepatoprotective flavonolignans silybins and isosilybins from the medicinal herb milk thistle (Silybum marianum) – volume: 39 start-page: 520 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0155 article-title: A review of Silybum marianum (milk thistle) as a treatment for alcoholic liver disease publication-title: J. Clin. Gastroenterol. doi: 10.1097/01.mcg.0000165668.79530.a0 – volume: 26 start-page: 155 year: 2001 ident: 10.1016/j.jpba.2016.05.034_bib0585 article-title: Determination of active component in silymarin by RP-LC and LC/MS publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(01)00364-8 – volume: 24 start-page: 466 year: 1974 ident: 10.1016/j.jpba.2016.05.034_bib0355 article-title: Chemistry and analysis of silymarin from Silybum marianum publication-title: Arzneim. −Forsch. – volume: 32A start-page: 877 year: 1996 ident: 10.1016/j.jpba.2016.05.034_bib0010 article-title: Antiproliferative effect of silybin on gynaecological malignancies: synergism with cisplatin and doxorubicin publication-title: Eur. J. Cancer doi: 10.1016/0959-8049(96)00011-1 – volume: 16 start-page: 2777 year: 1993 ident: 10.1016/j.jpba.2016.05.034_bib0500 article-title: Diastereomeric separation of free and conjugated silibinin in plasma by reversed phase HPLC after specific extraction publication-title: J. Liq. Chromatogr. doi: 10.1080/10826079308019612 – volume: 20 start-page: 25 year: 1992 ident: 10.1016/j.jpba.2016.05.034_bib0570 article-title: Pyrolysis gas chromatography-mass spectrometry for the rapid analysis of phenolics in Silybum marianum (L.) Gaertn publication-title: Chim. Acta Turc. – volume: 108 start-page: 790 year: 1975 ident: 10.1016/j.jpba.2016.05.034_bib0190 article-title: Struktur des silybins: I. Abbauversuche publication-title: Chem. Ber. doi: 10.1002/cber.19751080312 – volume: 31B start-page: 876 year: 1976 ident: 10.1016/j.jpba.2016.05.034_bib0210 article-title: Silydianin and silychristin, two isomeric silymarins from Silybum marianum L. Gaertin. (milk thistle) publication-title: Z. Naturforsch. B Anorg. Chem., Org. Chem. – volume: 281 start-page: 263 year: 1983 ident: 10.1016/j.jpba.2016.05.034_bib0380 article-title: Quantitative determination of biologically active constituents in medicinal plant crude extracts by thin-layer chromatography-densitometry publication-title: J. Chromatogr. A. doi: 10.1016/S0021-9673(01)87884-5 – year: 1996 ident: 10.1016/j.jpba.2016.05.034_bib0360 – volume: 15 start-page: 9 issue: 2008 year: 2006 ident: 10.1016/j.jpba.2016.05.034_bib0125 article-title: An updated systematic review with meta-analysis for the clinical evidence of silymarin publication-title: Forschen. Komplementärmedizin – volume: 13 start-page: 1234 year: 2001 ident: 10.1016/j.jpba.2016.05.034_bib0345 article-title: Spectrophotometric determination of silymarin publication-title: Asian J. Chem. – volume: 59 start-page: 230 year: 1997 ident: 10.1016/j.jpba.2016.05.034_bib0340 article-title: Spectrophotometric determination of silymarin publication-title: Indian J. Pharm. Sci. – volume: 73 start-page: 1214 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0255 article-title: Silyamandin, new flavonolignan isolated from milk thistle tinctures publication-title: Planta Med. doi: 10.1055/s-2007-981595 – volume: 105 start-page: 891 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0400 article-title: Extraction of nutraceuticals from milk thistle Part II. Extraction with organic solvents publication-title: Appl. Biochem. Biotechnol. doi: 10.1385/ABAB:108:1-3:891 – volume: 4 start-page: 204 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0065 article-title: Silymarin as a natural antioxidant: an overview of the current evidence and perspectives publication-title: Antioxidants (Basel, Switzerland) – volume: 107 start-page: 5995 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0005 article-title: Identification of hepatoprotective flavonolignans from silymarin publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0914009107 – volume: 27 start-page: 10 year: 2012 ident: 10.1016/j.jpba.2016.05.034_bib0080 article-title: Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease publication-title: J. Vet. Intern. Med. doi: 10.1111/jvim.12002 – volume: 37 start-page: 133 year: 2000 ident: 10.1016/j.jpba.2016.05.034_bib0335 article-title: Colorimetric estimation of silymarin in pharmaceutical dosage form publication-title: Indian Drugs. – volume: 30 start-page: 613 year: 2002 ident: 10.1016/j.jpba.2016.05.034_bib0455 article-title: Stability of the constituents of Calendula, Milk-thistle and Passionflower tinctures by LC-DAD and LC-MS publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(02)00352-7 – volume: 27 start-page: 261 year: 2001 ident: 10.1016/j.jpba.2016.05.034_bib0325 article-title: Dissolution test for silymarin tablets and capsules publication-title: Drug Dev. Ind. Pharm. doi: 10.1081/DDC-100000244 – volume: 862 start-page: 51 year: 2008 ident: 10.1016/j.jpba.2016.05.034_bib0555 article-title: Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2007.10.040 – volume: 77 start-page: 193 year: 2014 ident: 10.1016/j.jpba.2016.05.034_bib0300 article-title: Flavonolignans from aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum) publication-title: J. Nat. Prod. doi: 10.1021/np400955q – volume: 70 start-page: 1424 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0465 article-title: Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass Spectrometry (LC-MS/IT-TOF) publication-title: J. Nat. Prod. doi: 10.1021/np070136b – volume: 18 start-page: 688 year: 1968 ident: 10.1016/j.jpba.2016.05.034_bib0175 article-title: Chemistry of silymarin (silybin), the active component of the Silybum marianum fruits (Carduus marianus) publication-title: Arzneim. − Forsch. – volume: 38 start-page: 564 year: 2005 ident: 10.1016/j.jpba.2016.05.034_bib0535 article-title: Simultaneous determination of abietane-type diterpenes, flavonolignans and phenolic compounds in compound preparations of Silybum marianum and Salvia miltiorrhiza by HPLC-DAD-ESI MS publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2005.01.021 – volume: 845 start-page: 95 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0550 article-title: Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry publication-title: J. Chromatogr. B-Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2006.07.063 – volume: 55 start-page: 2532 year: 2007 ident: 10.1016/j.jpba.2016.05.034_bib0505 article-title: Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites publication-title: J. Agric. Food Chem. doi: 10.1021/jf063156c – volume: 37 year: 2015 ident: 10.1016/j.jpba.2016.05.034_bib0050 article-title: Silymarin: an insight to its formulation and analytical prospects publication-title: Acta Physiol. Plant doi: 10.1007/s11738-015-2008-3 – volume: 47 start-page: 2813 year: 2014 ident: 10.1016/j.jpba.2016.05.034_bib0620 article-title: Electrochemical determination of capsaicin and silymarin using a glassy carbon electrode modified by gold nanoparticle decorated multiwalledcarbon nanotubes publication-title: Anal. Lett. doi: 10.1080/00032719.2014.924010 – volume: 18 start-page: 2960 year: 2004 ident: 10.1016/j.jpba.2016.05.034_bib0590 article-title: Analysis of silymarin extracted from a commercial dosage by combining liquid–liquid extraction with negative electrospray tandem mass spectrometry publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.1700 – volume: 153 start-page: 227 year: 1978 ident: 10.1016/j.jpba.2016.05.034_bib0440 article-title: High-performance liquid chromatography of silymarin. II. Quantitative determination of silymarin from Silybum marianum by high-performance liquid chromatography publication-title: J. Chromatogr doi: 10.1016/S0021-9673(00)89876-3 – volume: 19 start-page: 435 year: 1999 ident: 10.1016/j.jpba.2016.05.034_bib0430 article-title: Determination of silymarine in the extract from the dried Silybum marianum fruits by high performance liquid chromatography and capillary electrophoresis publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/S0731-7085(98)00231-3 – volume: 53 start-page: 210 year: 2000 ident: 10.1016/j.jpba.2016.05.034_bib0450 article-title: Characterization of calendula flower, milk-thistle fruit, and passion flower tinctures by HPLC-DAD and HPLC-MS publication-title: Chromatographia doi: 10.1007/BF02491573 – volume: 9 start-page: 2911 year: 1968 ident: 10.1016/j.jpba.2016.05.034_bib0185 article-title: The structure of silybin (Silybum substance E6), the first flavonolignan publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)89610-0 – volume: 1 start-page: 1684 year: 2003 ident: 10.1016/j.jpba.2016.05.034_bib0230 article-title: Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum) publication-title: Org. Biomol. Chem. doi: 10.1039/b300099k – volume: 53 start-page: 1053 year: 2010 ident: 10.1016/j.jpba.2016.05.034_bib0560 article-title: Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2010.07.003 – volume: 30 start-page: 39 year: 1980 ident: 10.1016/j.jpba.2016.05.034_bib0365 article-title: Determination of silybin in raw materials and substances publication-title: Farmatsiya (Sofia) – volume: 36 start-page: 65 year: 2008 ident: 10.1016/j.jpba.2016.05.034_bib0460 article-title: Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.107.017566 – volume: 84 start-page: 223 year: 2011 ident: 10.1016/j.jpba.2016.05.034_bib0615 article-title: Stripping voltammetric determination of silymarin in formulations and human blood utilizing bare and modified carbon paste electrodes publication-title: Talanta doi: 10.1016/j.talanta.2011.01.027 – volume: 31 start-page: 1138 year: 2014 ident: 10.1016/j.jpba.2016.05.034_bib0075 article-title: Chemistry of silybin publication-title: Nat. Prod. Rep. doi: 10.1039/C3NP70122K |
| SSID | ssj0005194 |
| Score | 2.4399858 |
| SecondaryResourceType | review_article |
| Snippet | [Display omitted]
•The chemistry of Silybum marianum flavonolignans was reviewed (23 compounds to date).•Methods of isolation and structure elucidation are... Extracts of milk thistle (Silybum marianum, Asteraceae) have been recognized for centuries as remedies for liver and gallbladder disorders. The active... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 301 |
| SubjectTerms | Animals Chemical analysis Chromatography, Thin Layer - methods Chromatography, Thin Layer - trends Flavonolignans Flavonolignans - analysis Flavonolignans - chemistry Humans Magnetic Resonance Spectroscopy - methods Milk thistle Plant Extracts - analysis Plant Extracts - chemistry Review Seeds - chemistry Silybum marianum Silybum marianum - chemistry Silymarin Silymarin - analysis Silymarin - chemistry Spectrophotometry, Ultraviolet - methods Spectrophotometry, Ultraviolet - trends |
| Title | Recent advances in the analysis of flavonolignans of Silybum marianum |
| URI | https://dx.doi.org/10.1016/j.jpba.2016.05.034 https://www.ncbi.nlm.nih.gov/pubmed/27321822 https://www.proquest.com/docview/1826704418 |
| Volume | 130 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQXHpBPFq6pSAjVVxKuonXsckRoUULlRASIHGz_ERBu8mqu1tpL_3tnUmcBQ5w4BTHshVrZjLzWZ75TMgPJ5m1sOlKjPci4dy6pLDOJq7QEhmrgrVNlu-1GN3zq4f8YY2cd7UwmFYZfX_r0xtvHXv6UZr9aVn2b8E4M4mIQQwakhasYOcSrfzXvxdpHllzGSIOTnB0LJxpc7yepga5hzLRsHcO-FvB6S3w2QShiy2yGdEjPWsXuE3WfLVDjm9a-unlCb17rqaandBjevNMTL3cJUPAiBBjaDz3n9GyooD_qI7EJLQONIz137qqx-VjBUEMe27L8dIsJnQCu2pdLSafyf3F8O58lMRrFBLLGZsn3jPhuXaaM8kMz43w2NYSpBPyzEHItuG0kC6znGtdgNvJUwEPkxaGh3TwhaxXdeW_ElifDE5L4bE-ThtWyMwPggyFBv0Kx3ok6-SnbOQYx6suxqpLJntSKHOFMldprkDmPfJzNWfaMmy8Ozrv1KJe2YmCEPDuvKNOhwp-IDwV0ZWvFzOFGyyZAio87ZG9VrmrdYBZIcM9-_bBr-6TT_iGsY7l38n6_M_CHwCImZvDxkoPycbZ5e_R9X8N5vEs |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9tAEB7RcGgvVd9NC3QrVVyKFXuz3sVHhECh0AiJIHFb7RMZJXbUJEj598zaa6Ie4MDJ1j7k1cx4vlntzLcAv6ygxuCmK9HO8YQxY5PCWJPYQonAWOWNabJ8x3x0zf7c5DdbcNzVwoS0yuj7W5_eeOvYMojSHMzLcnCFxpmJEDHwYUPS8gq2AztV3oPto7Pz0XiT6ZE19yGG8UmYEGtn2jSvu7kO9EMZbwg8h-wpfHoq_mxw6PQdvI0BJDlq1_getlz1AfYvWwbq9QGZbAqqFgdkn1xuuKnXH-EEw0SEGRKP_hekrAiGgERFbhJSe-Kn6r6u6ml5WyGOhZarcrrWqxmZ4cZaVavZJ7g-PZkcj5J4k0JiGKXLxDnKHVNWMSqoZrnmLrwrgdLxeWYRtY0_LITNDGNKFeh58pTjQ6eFZj4dfoZeVVfuK-D6hLdKcBdK5JSmhcjc0AtfKFQxt7QPWSc_aSLNeLjtYiq7fLI7GWQug8xlmkuUeR9-P86ZtyQbz47OO7XI_0xFIgo8O-9np0OJ_1A4GFGVq1cLGfZYIsXA8LAPX1rlPq4DLSuQ3NNvL_zqD3g9mvy9kBdn4_Pv8Cb0BOij-Q70lv9WbhdjmqXeizb7AFVu890 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Recent+advances+in+the+analysis+of+flavonolignans+of+Silybum+marianum&rft.jtitle=Journal+of+pharmaceutical+and+biomedical+analysis&rft.au=Csupor%2C+Dezs%C5%91&rft.au=Csorba%2C+Attila&rft.au=Hohmann%2C+Judit&rft.date=2016-10-25&rft.issn=0731-7085&rft.volume=130&rft.spage=301&rft.epage=317&rft_id=info:doi/10.1016%2Fj.jpba.2016.05.034&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jpba_2016_05_034 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0731-7085&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0731-7085&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0731-7085&client=summon |