The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis

• Published in: Pharmacological research Vol. 165; p. 105420
• Main Authors: Liu, Pinyi, Wang, Yanbing, Yang, Ge, Zhang, Qihe, Meng, Lingbin, Xin, Ying, Jiang, Xin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2021
• Subjects: Animals; Carcinogenesis; Carcinogenesis - metabolism; Colonic Neoplasms - etiology; Colonic Neoplasms - metabolism; Fatty Acids, Volatile - metabolism; Fatty Acids, Volatile - physiology; Humans; Inflammation; Inflammation - metabolism; Intestinal barrier; Intestinal Mucosa - metabolism; Oxidative Stress; Short-chain fatty acids; Sirtuins; Oxidative stress; ABC; ACSSs; HDACs; cAMP; Carcinogenesis; PTS; SMCT-1; HCAR2; CBP; AMPs; CREB; MUC2; OLFR78; Nrf2; GPCRs; RNS; FFAR3; EC50; miRNA; HDACi; Short-chain fatty acids; Intestinal barrier; GLP-1; VEGF; PKC; Inflammation; FMLP; SOD2; ERK1/2; TCA; ZO-1; CRC; CAT; ROS; SCFAs; HATs; TEER; PEP; MCT-1

[Display omitted] •Short-chain fatty acids are metabolites produced in the intestinal tract.•Two major SCFA signaling mechanisms are promotion of histone acetylation and activation of G-protein-coupled receptors.•SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier functio...