The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis
[Display omitted] •Short-chain fatty acids are metabolites produced in the intestinal tract.•Two major SCFA signaling mechanisms are promotion of histone acetylation and activation of G-protein-coupled receptors.•SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier functio...
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| Published in | Pharmacological research Vol. 165; p. 105420 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.03.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Display omitted]
•Short-chain fatty acids are metabolites produced in the intestinal tract.•Two major SCFA signaling mechanisms are promotion of histone acetylation and activation of G-protein-coupled receptors.•SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress.•SCFAs have a high potential for a therapeutic use in human diseases
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases. |
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| AbstractList | Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases. Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases.Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases. [Display omitted] •Short-chain fatty acids are metabolites produced in the intestinal tract.•Two major SCFA signaling mechanisms are promotion of histone acetylation and activation of G-protein-coupled receptors.•SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress.•SCFAs have a high potential for a therapeutic use in human diseases Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carcinogenesis, intestinal barrier function, and oxidative stress, but convincing evidence in humans is still lacking. Two major SCFA signaling mechanisms have been identified: promotion of histone acetylation and activation of G-protein-coupled receptors. In this review, we introduce the production and metabolic characteristics of SCFAs, summarize the potential effects of SCFAs on the four aspects mentioned above and the possible mechanisms. SCFAs have been reported to exert a wide spectrum of positive effects and have a high potential for therapeutic use in human-related diseases. |
| ArticleNumber | 105420 |
| Author | Wang, Yanbing Meng, Lingbin Jiang, Xin Liu, Pinyi Yang, Ge Zhang, Qihe Xin, Ying |
| Author_xml | – sequence: 1 givenname: Pinyi surname: Liu fullname: Liu, Pinyi email: liupy18@mails.jlu.edu.cn organization: Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China – sequence: 2 givenname: Yanbing surname: Wang fullname: Wang, Yanbing email: drwyb@163.com organization: Department of Orthopedic, The Second Hospital of Jilin University, Changchun, 130041, China – sequence: 3 givenname: Ge surname: Yang fullname: Yang, Ge email: yangge19@jlu.edu.cn organization: Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China – sequence: 4 givenname: Qihe surname: Zhang fullname: Zhang, Qihe email: qhzhang19@mails.jlu.edu.cn organization: Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China – sequence: 5 givenname: Lingbin surname: Meng fullname: Meng, Lingbin email: lingbin.meng@moffitt.org organization: Department of Hematology and Medical Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA – sequence: 6 givenname: Ying surname: Xin fullname: Xin, Ying email: xiny@jlu.edu.cn organization: Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China – sequence: 7 givenname: Xin surname: Jiang fullname: Jiang, Xin email: jiangx@jlu.edu.cn organization: Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33434620$$D View this record in MEDLINE/PubMed |
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•Short-chain fatty acids are metabolites produced in the intestinal tract.•Two major SCFA signaling mechanisms are promotion of histone... Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary... |
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| SubjectTerms | Animals Carcinogenesis Carcinogenesis - metabolism Colonic Neoplasms - etiology Colonic Neoplasms - metabolism Fatty Acids, Volatile - metabolism Fatty Acids, Volatile - physiology Humans Inflammation Inflammation - metabolism Intestinal barrier Intestinal Mucosa - metabolism Oxidative Stress Short-chain fatty acids |
| Title | The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis |
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