Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter

• Published in: Nature communications Vol. 16; no. 1; pp. 1892 - 15
• Main Authors: Li, Tao, Zong, Qingyu, Dong, He, Ullah, Ihsan, Pan, Zhenhai, Yuan, Youyong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/19; 14/34; 631/45/474/2085; 639/301/54/1754; 64; 64/60; 82/1; 82/80; 96; Animal models; Animals; Biodegradation; Cell Line, Tumor; Chimeras; Degradation; Environmental degradation; Genes, Reporter; Humanities and Social Sciences; Humans; Invasiveness; Mice; Monitoring; multidisciplinary; Proteins; Proteolysis; Science; Science (multidisciplinary); Therapeutic applications; Therapeutic targets; Western blotting

Proteolysis targeting chimeras (PROTACs) represent a groundbreaking therapeutic technology for selectively degrading proteins of interest (POIs). The structural variations in PROTACs unpredictably influence their protein degradation efficiency, which is predominantly assessed by quantifying POIs abu...