Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22

• Published in: World journal of gastroenterology : WJG Vol. 18; no. 36; pp. 5122 - 5128
• Main Author: Huai, Jia-Ping
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 28.09.2012
• Subjects: Acute Disease; Acute Lung Injury - drug therapy; Amylases - blood; Animals; Brief; Immunity, Innate; Interleukin-22; Interleukins - physiology; Lung - pathology; Male; Melatonin - pharmacology; Melatonin - therapeutic use; Pancreatitis - complications; Pancreatitis - pathology; Rats; Rats, Sprague-Dawley; SD大鼠; 保护作用; 激素治疗; 白细胞介素; 肺损伤; 血清样品; 褪黑激素; 重症急性胰腺炎; Interleukin 22; Melatonin; Pancreatitis-associated lung injury; Severe acute pancreatitis; T helper 22 cell

AIM： To investigate whether therapeutic treatment with melatonin could protect rats against acute pan- creatitis and its associated lung injury. METHODS： Seventy-two male Sprague-Dawley rats were randomly divided into three groups： the sham op- eration （SO）, severe acute pancreatitis （SAP）, and mel-...