Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer - Alexander, Matthew S.; Wilkes, Justin G.; Schroeder, Samuel R.; Buettner, Garry R.; Wagner, Brett A.; Du, Juan; Gibson-Corley, Katherine; O’Leary, Brianne R.; Spitz, Douglas R.; Buatti, John M.; Berg, Daniel J.; Bodeker, Kellie L.; et al. (Cancer research (Chicago, Ill.), 2018)
Keywords: Aged; Aged, 80 and over; Animals; Ascorbic Acid - pharmacology; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen - metabolism; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Disease-Free Survival; DNA Damage; Female; Glutathione - metabolism; Humans; Male; Mice; Mice, Nude; Middle Aged; Oxidative Stress; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - radiotherapy; Radiation Tolerance; Radiotherapy; Recombinant Proteins - metabolism; Treatment Outcome