The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation

• Published in: Oncotarget Vol. 7; no. 47; pp. 77865 - 77877
• Main Authors: El Zawily, Amr M, Toosi, Behzad M, Freywald, Tanya, Indukuri, Vijaya V, Vizeacoumar, Franco J, Leary, Scot C, Freywald, Andrew
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 22.11.2016
• Subjects: Apoptosis - physiology; Cell Line, Tumor; GTP Phosphohydrolases - metabolism; Humans; MAP Kinase Signaling System; Microtubule-Associated Proteins - metabolism; Mitochondria - metabolism; Mitochondrial Proteins - metabolism; Receptors, Eph Family - metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism; Research Paper; Triple Negative Breast Neoplasms - enzymology; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; EPHB6; cancer; DR5; DRP1; mitochondrial dynamics

Death Receptor 5 (DR5) is a promising target for cancer therapy due to its ability to selectively induce apoptosis in cancer cells. However, the therapeutic usefulness of DR5 agonists is currently limited by the frequent resistance of malignant tumours to its activation. The identification of molecu...