Blocking of Birc3/TLR4/Myd88 signaling protects carbapenem-resistant klebsiella pneumoniae in a mouse model of infection

• Published in: Transplant immunology Vol. 69; p. 101464
• Main Authors: Li, Sujuan, Yang, Ping, Xu, Lijuan, Li, Minmin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Baculoviral IAP Repeat-Containing 3 Protein - antagonists & inhibitors; Baculoviral IAP Repeat-Containing 3 Protein - physiology; Birc3; Carbapenems; CRKP resistance; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Mice; Myeloid Differentiation Factor 88; Pneumonia, Bacterial - drug therapy; Pneumonia, Bacterial - microbiology; Signal Transduction; Toll-Like Receptor 4; TNFR; TCR; KP; Birc3; BIR; CRKP; Myd88; CRKP resistance; TAK1; Car; LB; TRAF6; CPE; PAMPs; Mice; TGF-βR; TLR4; Klebsiella pneumoniae; MDR-KP; TLRs; ELISA

Klebsiella pneumonia (KP) and carbapenem-resistant Klebsiella pneumonia (CRKP) lung infections significantly increase the morbidity and mortality of pneumonia. Recent studies have shown that baculoviral IAP repeat-containing 3 (Birc3) plays an important role in the prevention and treatment of pneumo...