Multimodal functional imaging and clinical correlates of pain regions in chronic low-back pain patients treated with spinal cord stimulation: a pilot study

• Published in: Frontiers in neuroimaging Vol. 3; p. 1474060
• Main Authors: Shamli Oghli, Yazan, Ashok, Arjun, Glener, Steven, Ailes, Isaiah, Syed, Mashaal, Kang, Ki Chang, Naghizadehkashani, Sara, Fayed, Islam, Mohamed, Feroze B., Talekar, Kiran, Krisa, Laura, Wu, Chengyuan, Matias, Caio, Alizadeh, Mahdi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.09.2024
• Subjects: chronic low-back pain; Neuroimaging; pain Neuromatrix; pseudo-continuous arterial spin labeling (PCASL); resting-state functional MRI (rs-fMRI); spinal cord stimulation; pain Neuromatrix; spinal cord stimulation; resting-state functional MRI (rs-fMRI); pseudo-continuous arterial spin labeling (PCASL); chronic low-back pain
• DOI: 10.3389/fnimg.2024.1474060
• ISSN: 2813-1193

Spinal cord stimulation (SCS) is an invasive treatment option for patients suffering from chronic low-back pain (cLBP). It is an effective treatment that has been shown to reduce pain and increase the quality of life in patients. However, the activation of pain processing regions of cLBP patients receiving SCS has not been assessed using objective, quantitative functional imaging techniques. The purpose of the present study was to compare quantitative resting-state (rs)-fMRI and arterial spin labeling (ASL) measures between SCS patients and healthy controls and to correlate clinical measures with quantitative multimodal imaging indices in pain regions. Multi-delay 3D GRASE pseudo-continuous ASL and rs-fMRI data were acquired from five patients post-SCS with cLBP and five healthy controls. Three ASL measures and four rs-fMRI measures were derived and normalized into MNI space and smoothed. Averaged values for each measure from a pain atlas were extracted and compared between patients and controls. Clinical pain scores assessing intensity, sensitization, and catastrophizing, as well as others assessing global pain effects (sleep quality, disability, anxiety, and depression), were obtained in patients and correlated with pain regions using linear regression analysis. Arterial transit time derived from ASL and several rs-fMRI measures were significantly different in patients in regions involved with sensation (primary somatosensory cortex and ventral posterolateral thalamus [VPL]), pain input (posterior short gyrus of the insula [PS]), cognition (dorsolateral prefrontal cortex [DLPC] and posterior cingulate cortex [PCC]), and fear/stress response (hippocampus and hypothalamus). Unidimensional pain rating and sensitization scores were linearly associated with PS, VPL, DLPC, PCC, and/or amygdala activity in cLBP patients. The present results provide evidence that ASL and rs-fMRI can contrast functional activation in pain regions of cLBP patients receiving SCS and healthy subjects, and they can be associated with clinical pain evaluations as quantitative assessment tools.