Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers

• Published in: Oncotarget Vol. 7; no. 52; pp. 86999 - 87015
• Main Authors: Hurwitz, Stephanie N, Rider, Mark A, Bundy, Joseph L, Liu, Xia, Singh, Rakesh K, Meckes, Jr, David G
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 27.12.2016
• Subjects: Biomarkers, Tumor - analysis; Cell Line, Tumor; Extracellular Vesicles - chemistry; Humans; Proteomics - methods; Research Paper; microvesicles; proteomics; biomarkers; co-inertia; exosomes

Packed with biological information, extracellular vesicles (EVs) offer exciting promise for biomarker discovery and applications in therapeutics and non-invasive diagnostics. Currently, our understanding of EV contents is confined by the limited cells from which vesicles have been characterized util...