Screening and mechanistic study of natural compounds that enhance T cell anti-tumor effects post-heat treatment

• Published in: Frontiers in immunology Vol. 16; p. 1537398
• Main Authors: Wang, Zhaoyi, Diao, Zhongqi, Zhang, Yiyan, Liu, Jiangying, Li, Yeshan, Sun, Zijin, Zhen, Huimin, Wang, Haojia, Yang, Siyun, Wang, Tieshan, Ni, Lei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.03.2025
• Subjects: adoptive cell therapy; Apoptosis - drug effects; Biological Products - pharmacology; Chinese medicine; Coculture Techniques; enhance immunity; Hot Temperature; Humans; Immunology; Immunotherapy, Adoptive - methods; Jurkat Cells; K562 Cells; Neoplasms - immunology; Neoplasms - therapy; proteomics; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; temperature; untargeted metabolomics; Chinese medicine; untargeted metabolomics; proteomics; RNA-Seq; enhance immunity; temperature; adoptive cell therapy

Following the approval of Chimeric Antigen Receptor T-cell Immunotherapy(CAR-T) in multiple countries, the Food and Drug Administration (FDA) approved tumor-infiltrating lymphocytes (TILs) and T-cell receptor-engineered T cells (TCR-T) treatments this year. The utilization of adoptive immunotherapy...