An Immune-Related Gene Prognostic Index for Head and Neck Squamous Cell Carcinoma

• Published in: Clinical cancer research Vol. 27; no. 1; pp. 330 - 341
• Main Authors: Chen, Yue, Li, Zhi-Yong, Zhou, Guan-Qun, Sun, Ying
• Format: Journal Article
• Language: English
• Published: United States 01.01.2021
• Subjects: Aged; Biomarkers, Tumor - genetics; Datasets as Topic; Drug Resistance, Neoplasm - genetics; Female; Follow-Up Studies; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - immunology; Gene Regulatory Networks - immunology; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - mortality; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Male; Middle Aged; Mutation; Prognosis; Risk Assessment - methods; Risk Assessment - statistics & numerical data; Squamous Cell Carcinoma of Head and Neck - drug therapy; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - immunology; Squamous Cell Carcinoma of Head and Neck - mortality; Treatment Outcome

To construct an immune-related gene prognostic index (IRGPI) for head and neck squamous cell carcinoma (HNSCC) and clarify the molecular and immune characteristics and the benefit of immune checkpoint inhibitor (ICI) therapy in IRGPI-defined subgroups of HNSCC. On the basis of The Cancer Genome Atla...