Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy

• Published in: Frontiers in immunology Vol. 16; p. 1536545
• Main Authors: Zhu, Jiahao, Xu, Benjie, Wu, Zhixing, Yu, Zhiwei, Ji, Shengjun, Lian, Jie, Lu, Haibo
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.03.2025
• Subjects: Biomarkers, Tumor - genetics; Cell Line, Tumor; colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Computational Biology - methods; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunology; immunotherapy; Immunotherapy - methods; Machine Learning; Prognosis; semaphorins; Semaphorins - genetics; Semaphorins - metabolism; single-cell sequencing; spatial transcriptome sequencing; Transcriptome; single-cell sequencing; colorectal cancer; semaphorins; spatial transcriptome sequencing; immunotherapy

Semaphorins (SEMAs), originally identified as axon guidance factors, have been found to play crucial roles in tumor growth, invasiveness, neoangiogenesis, and the modulation of immune responses. However, the prognostic value of SEMA-related genes in colorectal cancer (CRC) remains unclear. We applie...