Mechanism of Resveratrol on LPS/ATP-induced pyroptosis and inflammatory response in HT29 cells

• Published in: Autoimmunity (Chur, Switzerland) Vol. 57; no. 1; p. 2427094
• Main Authors: Zhao, Peizhuang, Ning, Jiajia, Huang, Jun, Huang, Xue
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.12.2024
• Subjects: Adenosine Triphosphate - metabolism; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; HT29 Cells; Humans; Inflammasomes - drug effects; Inflammasomes - metabolism; Inflammation - drug therapy; Inflammation - immunology; Inflammation - metabolism; Lipopolysaccharides - immunology; NF-kappa B - metabolism; NF-κB pathway; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 inflammasome; pyroptosis; Pyroptosis - drug effects; resveratrol; Resveratrol - pharmacology; Signal Transduction - drug effects; Ulcerative colitis; pyroptosis; NLRP3 inflammasome; resveratrol; NF-κB pathway; Ulcerative colitis

Pyroptosis plays an important role in maintenance of intestinal homeostasis, the abnormal activation of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome can promote the event and development of ulcerative colitis (UC). Its protective effects such as inhibiting pyrop...