Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population

• Published in: Frontiers in genetics Vol. 16; p. 1582718
• Main Authors: Wang, Jinxin, Chen, Weicheng, Huang, Xianghui, Gao, Han, Feng, Zhiyu, Tan, Chaozhong, Zhuang, Quannan, Gao, Yuan, Min, Shaojie, Lu, Yuquan, Wu, Feizhen, Qian, Maoxiang, Yan, Weili, Sheng, Wei, Huang, Guoying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.05.2025
• Subjects: candidate genes; Chinese populations; congenital heart disease; Genetics; laterality defects; pathogenic variants; congenital heart disease; Chinese populations; laterality defects; candidate genes; pathogenic variants

Congenital heart disease (CHD) is often accompanied by laterality defects (LD), giving rise to a severe and intricate form of congenital anomaly. The aim of this study was to explore the genetic etiology of CHD/LD in the Chinese population. We recruited 52 Chinese CHD family trios between January 20...