Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity–breast cancer link

• Published in: International Journal of Obesity Vol. 42; no. 4; pp. 711 - 720
• Main Authors: Zahid, H, Subbaramaiah, K, Iyengar, N M, Zhou, X K, Chen, I-C, Bhardwaj, P, Gucalp, A, Morrow, M, Hudis, C A, Dannenberg, A J, Brown, K A
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2018
• Subjects: 14/19; 38/89; 631/67; 631/80/86; 64/60; 692/499; 692/699/2743; 692/699/2743/393; 692/699/67/1347; 82/1; 96/106; 96/109; 96/95; Adipocytes - metabolism; Animals; Aromatase - genetics; Aromatase - metabolism; Body Mass Index; Breast - cytology; Breast - metabolism; Breast Neoplasms - metabolism; Carrier Proteins - metabolism; Cells, Cultured; Epidemiology; Female; Health Promotion and Disease Prevention; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Internal Medicine; Leptin - metabolism; Mammary Glands, Animal - metabolism; Medicine; Medicine & Public Health; Membrane Proteins - metabolism; Metabolic Diseases; Mice; Obesity - metabolism; original-article; Public Health; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones - metabolism; Tumor Suppressor Protein p53 - metabolism

Background/Objectives: Obesity (body mass index (BMI)⩾30 kg m −2 ) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elevated in breast tissue of obese women. Recently, the regulation...