Characterisation of the cancer-associated glucocorticoid system: key role of 11β-hydroxysteroid dehydrogenase type 2

• Published in: British journal of cancer Vol. 117; no. 7; pp. 984 - 993
• Main Authors: Cirillo, Nicola, Morgan, David J, Pedicillo, Maria Carmela, Celentano, Antonio, Lo Muzio, Lorenzo, McCullough, Michael J, Prime, Stephen S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.09.2017; Nature Publishing Group
• Subjects: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - analysis; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - antagonists & inhibitors; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism; 631/67/1813/1352; 631/67/2327; 631/67/327; Adrenocorticotropic Hormone - pharmacology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - enzymology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell Adhesion; Cell Proliferation - drug effects; Cortisone - pharmacology; Culture Media, Conditioned - pharmacology; Down-Regulation; Drug Resistance; Epidemiology; Epithelial Cells - enzymology; Gene Silencing; Glycyrrhetinic Acid - analogs & derivatives; Glycyrrhetinic Acid - pharmacology; HT29 Cells; Humans; Hydrocortisone - immunology; Hydrocortisone - metabolism; Hydrocortisone - pharmacology; Keratinocytes - drug effects; Keratinocytes - metabolism; MCF-7 Cells; Melanoma - chemistry; Melanoma - enzymology; Molecular Diagnostics; Molecular Medicine; Oncology; Paracrine Communication; Receptors, Glucocorticoid - immunology; Receptors, Glucocorticoid - metabolism; Skin Neoplasms - chemistry; Skin Neoplasms - enzymology; 11; cortisol; lymphocytes; cell adhesion; cancer; HSDs; keratinocytes

Background: Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and cortisol is regulated by the 11 β -hydroxysteroid dehydrogenases (11 β -HSDs). However...