Stem cell factor-mediated wild-type KIT receptor activation is critical for gastrointestinal stromal tumor cell growth

• Published in: World journal of gastroenterology : WJG Vol. 18; no. 23; pp. 2929 - 2937
• Main Author: Bai, Chen-Guang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 21.06.2012
• Subjects: Adult; Aged; Apoptosis - drug effects; Cell Proliferation - drug effects; Female; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gastrointestinal Neoplasms - pathology; Gastrointestinal Stromal Tumors - genetics; Gastrointestinal Stromal Tumors - metabolism; Gastrointestinal Stromal Tumors - pathology; Genotype; Humans; Male; Middle Aged; Mitotic Index; Mutation; Original; Proto-Oncogene Proteins c-kit - drug effects; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Stem Cell Factor - metabolism; Stem Cell Factor - pharmacology; Tumor Cells, Cultured; 介导; 受体; 干细胞因子; 激活; 细胞生长; 胃肠道; 野生型; Cell growth; Wild-type KIT receptor; In vitro; Gastrointestinal stromal tumor; Stem cell factor

AIM： To clarify the biological role of stem cell factor （SCF）-mediated wild-type KIT receptor activation in gastrointestinal stromal tumor （GIST） growth. METHODS： The co-expression of wild-type KIT receptor and SCF was evaluated in 51 GIST samples using mutation analysis and immunohistochemistry, an...