Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy

• Published in: Pharmacological research Vol. 168; p. 105580
• Main Authors: Zheng, Kai, Dong, Yun, Yang, Rong, Liang, Youfang, Wu, Haiqiang, He, Zhendan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2021
• Subjects: Cancer therapy; Dietary Supplements; Ferroptosis; Ferroptosis - drug effects; Humans; Iron - metabolism; Lipid peroxidation; Mevalonic Acid - metabolism; Natural phytochemicals; Neoplasms - drug therapy; NRF2; Oxidative Stress - drug effects; Phospholipids - metabolism; Phytochemicals - pharmacology; Plant Extracts - pharmacology; Reactive oxygen species; Iron metabolism; Reactive oxygen species; NRF2; Cancer therapy; Lipid peroxidation; Ferroptosis; Natural phytochemicals

Ferroptosis is an iron- and lipotoxicity-dependent regulated cell death that has been implicated in various diseases, such as cancer, neurodegeneration and stroke. The biosynthesis of phospholipids, coenzyme Q10, and glutathione, and the metabolism of iron, amino acids and polyunsaturated fatty acid...