The structural plasticity of the human copper chaperone for SOD1: insights from combined size-exclusion chromatographic and solution X-ray scattering studies

• Published in: Biochemical journal Vol. 439; no. 1; p. 39
• Main Authors: Wright, Gareth S A, Hasnain, S Samar, Grossmann, J Günter
• Format: Journal Article
• Language: English
• Published: England 01.10.2011
• Subjects: Amino Acid Sequence; Chromatography, Gel - methods; Humans; Molecular Chaperones - chemistry; Molecular Chaperones - metabolism; Molecular Sequence Data; Protein Structure, Secondary; Scattering, Radiation; X-Rays

The incorporation of copper into biological macromolecules such as SOD1 (Cu,Zn superoxide dismutase) is essential for the viability of most organisms. However, copper is toxic and therefore the intracellular free copper concentration is kept to an absolute minimum. Several proteins, termed metalloch...