Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis

• Published in: Pharmacological research Vol. 165; p. 105447
• Main Authors: He, Xiao, Fan, Xuehui, Bai, Bing, Lu, Nanjuan, Zhang, Shuang, Zhang, Liming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2021
• Subjects: Animals; Atherosclerosis; Atherosclerosis - immunology; Atherosclerosis - metabolism; Cholesterol crystals; Endothelial Cells - immunology; Endothelial Cells - metabolism; Humans; Immunity, Cellular - immunology; Inflammation Mediators - immunology; Inflammation Mediators - metabolism; Lipoproteins, LDL - immunology; Lipoproteins, LDL - metabolism; Macrophages - immunology; Macrophages - metabolism; Myocytes, Smooth Muscle - immunology; Myocytes, Smooth Muscle - metabolism; ox-LDL; Pyroptosis; Pyroptosis - immunology; NADPH; DY9836 (PubChem CID:9801925); COX-2; MCC950 (PubChem CID: 9910393); mtDNA; Leu-Leu-OMe (PubChem CID:7016877); 4-PBA (PubChem CID:83242); ICAM-1; HO-1; HMGB1; cAMP; INF39 (PubChem CID: 69150705); DAMPs; LDH; Cholesterol crystals; UPR; CA-074-Me (PubChem CID:6610318); Atherosclerosis; BKCa; PAMPs; CHOP; mtROS; mTOP; z-VAD-fmk (PubChem CID:87146076); ASCs; AMI; VX-765 (PubChem CID:11398092); GSDMD; XBP1; Pyroptosis; MMPs; Taurine (PubChem CID:1123); TET2; CHCs; ox-LDL; ER; VCAM-1; NOX; ROS; VDAC; TXNIP; SiNPs; MAMs; m6A; MALAT1; TLRs; BMS-345541 (PubChem CID:9926054)

[Display omitted] Pyroptosis is a form of programmed cell death activated by various stimuli and is characterized by inflammasome assembly, membrane pore formation, and the secretion of inflammatory cytokines (IL-1β and IL-18). Atherosclerosis-related risk factors, including oxidized low-density lip...