Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps

• Published in: Bioorganic & medicinal chemistry letters Vol. 28; no. 7; pp. 1194 - 1197
• Main Authors: Zhang, Jie, Sasaki, Tatsunori, Li, Wei, Nagata, Kazuya, Higai, Koji, Feng, Feng, Wang, Jian, Cheng, Maosheng, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.04.2018
• Subjects: Artemisia - chemistry; Artemisia princeps; Caffeoylquinic acid; Chlorogenic acid; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Protein tyrosine phosphatase 1B; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism; Quinic Acid - analogs & derivatives; Quinic Acid - chemical synthesis; Quinic Acid - chemistry; Quinic Acid - pharmacology; Structure-Activity Relationship; Protein tyrosine phosphatase 1B; Chlorogenic acid; Artemisia princeps; Caffeoylquinic acid; CWVRJTMFETXNAD-JUHZACGLSA-N

[Display omitted] •Caffeoylquinic acid derivatives are natural PTP1B inhibitors.•Chlorogenic acid showed potent PTP1B inhibitory activity.•Chlorogenic acid is a noncompetitive inhibitor.•Chlorogenic acid binds to the allosteric site of PTP1B. Considerable attention has been paid to protein tyrosine...