Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells - Kurosawa, Toshiki; Higuchi, Kei; Okura, Takashi; Kobayashi, Kazumasa; Kusuhara, Hiroyuki; Deguchi, Yoshiharu (Journal of pharmaceutical sciences, 2017)
Keywords: Animals; Antiporters - chemistry; Antiporters - metabolism; basic drug; Biological Transport; blood-brain barrier; Blood-Brain Barrier - metabolism; Brain - drug effects; Brain - metabolism; Diphenhydramine - chemistry; Diphenhydramine - metabolism; Endothelial Cells - metabolism; Endothelium, Vascular - metabolism; Humans; Kinetics; Male; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - chemistry; Nicotinic Agonists - metabolism; Organic Cation Transport Proteins - metabolism; organic cation transporter; Protons; Rats; Receptors, Nicotinic - metabolism; Thermodynamics; varenicline; Varenicline - administration & dosage; Varenicline - chemistry; Varenicline - metabolism; basic drug; blood-brain barrier; varenicline; organic cation transporter