IDO1-mediated M2 macrophage polarization alleviates the progression of ankylosing spondylitis

• Published in: Autoimmunity (Chur, Switzerland) Vol. 58; no. 1; p. 2441134
• Main Authors: Ji, Kangqi, Wang, Lingfei, Liu, Weijie, Li, Genfeng, Lian, Xiaoyu, Fan, Jun, Song, Chen, Jian, Yanpeng
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.12.2025
• Subjects: Ankylosing spondylitis; Cell Differentiation - immunology; Cell Proliferation; Disease Progression; Female; Humans; IDO1; Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; M2 macrophage polarization; Macrophage Activation - genetics; Macrophage Activation - immunology; Macrophages - immunology; Macrophages - metabolism; Male; Mesenchymal Stem Cells - metabolism; Osteogenesis - genetics; Osteogenic differentiation; PPAR gamma - genetics; PPAR gamma - metabolism; PPARγ; Signal Transduction; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - immunology; Spondylitis, Ankylosing - metabolism; Spondylitis, Ankylosing - pathology; THP-1 Cells; M2 macrophage polarization; Osteogenic differentiation; Ankylosing spondylitis; PPARγ; IDO1

Indoleamine 2,3-dioxygenase 1 (IDO1) plays an anti-inflammatory role in autoimmune disease. However, its specific function in ankylosing spondylitis (AS) remain unclear. This study aimed to investigate the potential role of IDO1 in AS. Immunofluorescence, RT-qPCR, and western blot assays were employ...