Poly(lactic acid) blends in biomedical applications

Poly(lactic acid) (PLA) has become a “material of choice” in biomedical applications for its ability to fulfill complex needs that typically include properties such as biocompatibility, biodegradability, mechanical strength, and processability. Despite the advantages of pure PLA in a wider spectrum...

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Published in	Advanced drug delivery reviews Vol. 107; pp. 47 - 59
Main Authors	Saini, P., Arora, M., Kumar, M.N.V. Ravi
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 15.12.2016
Subjects	Biocompatible Biocompatible Materials - chemistry Biodegradable Blends Drug delivery Drug Delivery Systems Humans Lactic Acid - chemistry Polyesters - chemistry Polymers - chemistry Tissue Engineering Biocompatible Drug delivery Biodegradable Blends Tissue engineering
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Abstract	Poly(lactic acid) (PLA) has become a “material of choice” in biomedical applications for its ability to fulfill complex needs that typically include properties such as biocompatibility, biodegradability, mechanical strength, and processability. Despite the advantages of pure PLA in a wider spectrum of applications, it is limited by its hydrophobicity, low impact toughness, and slow degradation rate. Blending PLA with other polymers offers a convenient option to enhance its properties or generate novel properties for target applications without the need to develop new materials. PLA blends with different natural and synthetic polymers have been developed by solvent and melt blending techniques and further processed based on end-use applications. A variety of PLA blends has been explored for biomedical applications such as drug delivery, implants, sutures, and tissue engineering. This review discusses the opportunities for PLA blends in the biomedical arena, including the overview of blending and postblend processing techniques and the applications of PLA blends currently in use and under development. [Display omitted]
AbstractList	Poly(lactic acid) (PLA) has become a "material of choice" in biomedical applications for its ability to fulfill complex needs that typically include properties such as biocompatibility, biodegradability, mechanical strength, and processability. Despite the advantages of pure PLA in a wider spectrum of applications, it is limited by its hydrophobicity, low impact toughness, and slow degradation rate. Blending PLA with other polymers offers a convenient option to enhance its properties or generate novel properties for target applications without the need to develop new materials. PLA blends with different natural and synthetic polymers have been developed by solvent and melt blending techniques and further processed based on end-use applications. A variety of PLA blends has been explored for biomedical applications such as drug delivery, implants, sutures, and tissue engineering. This review discusses the opportunities for PLA blends in the biomedical arena, including the overview of blending and postblend processing techniques and the applications of PLA blends currently in use and under development. Poly(lactic acid) (PLA) has become a “material of choice” in biomedical applications for its ability to fulfill complex needs that typically include properties such as biocompatibility, biodegradability, mechanical strength, and processability. Despite the advantages of pure PLA in a wider spectrum of applications, it is limited by its hydrophobicity, low impact toughness, and slow degradation rate. Blending PLA with other polymers offers a convenient option to enhance its properties or generate novel properties for target applications without the need to develop new materials. PLA blends with different natural and synthetic polymers have been developed by solvent and melt blending techniques and further processed based on end-use applications. A variety of PLA blends has been explored for biomedical applications such as drug delivery, implants, sutures, and tissue engineering. This review discusses the opportunities for PLA blends in the biomedical arena, including the overview of blending and postblend processing techniques and the applications of PLA blends currently in use and under development. [Display omitted]
Author	Saini, P. Kumar, M.N.V. Ravi Arora, M.
Author_xml	– sequence: 1 givenname: P. orcidid: 0000-0002-7799-7748 surname: Saini fullname: Saini, P. – sequence: 2 givenname: M. surname: Arora fullname: Arora, M. – sequence: 3 givenname: M.N.V. Ravi surname: Kumar fullname: Kumar, M.N.V. Ravi email: mnvrkumar@tamhsc.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27374458$$D View this record in MEDLINE/PubMed
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Snippet	Poly(lactic acid) (PLA) has become a “material of choice” in biomedical applications for its ability to fulfill complex needs that typically include properties... Poly(lactic acid) (PLA) has become a "material of choice" in biomedical applications for its ability to fulfill complex needs that typically include properties...
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SubjectTerms	Biocompatible Biocompatible Materials - chemistry Biodegradable Blends Drug delivery Drug Delivery Systems Humans Lactic Acid - chemistry Polyesters - chemistry Polymers - chemistry Tissue Engineering
Title	Poly(lactic acid) blends in biomedical applications
URI	https://dx.doi.org/10.1016/j.addr.2016.06.014 https://www.ncbi.nlm.nih.gov/pubmed/27374458 https://www.proquest.com/docview/1826716459
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