CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

• Published in: The Journal of experimental medicine Vol. 218; no. 10
• Main Authors: Greaves, Sarah A., Ravindran, Avinash, Santos, Radleigh G., Chen, Lan, Falta, Michael T., Wang, Yang, Mitchell, Angela M., Atif, Shaikh M., Mack, Douglas G., Tinega, Alex N., Maier, Lisa A., Dai, Shaodong, Pinilla, Clemencia, Grunewald, Johan, Fontenot, Andrew P.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.10.2021
• Subjects: Adult; Animals; Antigens, Fungal - immunology; Aspergillus nidulans - immunology; Case-Control Studies; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - microbiology; Epitopes, T-Lymphocyte - immunology; Female; Fungal Proteins - immunology; HLA-DR3 Antigen - chemistry; HLA-DR3 Antigen - genetics; HLA-DR3 Antigen - immunology; Humans; Hybridomas - immunology; Immunoglobulin G; Male; Mice, Transgenic; Middle Aged; Mucosal Immunology; Sarcoidosis - immunology

Löfgren’s syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified...