Association of 25-hydroxyvitamin D with Parkinson’s disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis

• Published in: Scientific reports Vol. 15; no. 1; pp. 5514 - 12
• Main Authors: Xu, Yan, Peng, Jie, Zhou, Xiguo, Huang, Yuexin, Zhong, Guanzhen, Xia, Zhiwei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 25-Hydroxyvitamin D; 631/378; 692/499; 692/617; 692/699; 692/700; Aged; Biomarkers; Cognitive ability; Demography; Female; Genetic analysis; Genome-wide association studies; Genome-Wide Association Study; Genomes; Humanities and Social Sciences; Humans; Influence; Male; Medical laboratories; Mendelian randomization; Mendelian Randomization Analysis; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; NHANES; Nutrition Surveys; Observational studies; Parkinson Disease - blood; Parkinson Disease - epidemiology; Parkinson Disease - genetics; Parkinson's disease; Pleiotropy; Polymorphism, Single Nucleotide; Regression analysis; Risk Factors; Science; Science (multidisciplinary); Sensitivity analysis; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin deficiency; NHANES; Mendelian randomization; 25-hydroxyvitamin D; Vitamin D; Parkinson’s disease

An abundance of observational researches had suggested that vitamin D insufficient was related to Parkinson’s disease (PD) risk. However, their relationships were debatable and the causality remains uncertain. We intended to evaluate the association between 25-hydroxyvitamin D [25(OH)D] and Parkinso...