Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

• Published in: Frontiers in immunology Vol. 16; p. 1511990
• Main Authors: Vincent, Laurence, Lapointe, Catherine, McDonald, Patrick P., Rammos, Christos, Rassaf, Tienush, Köllnberger, Maria, Tinel, Hanna, Heitmeier, Stefan, D’Orléans-Juste, Pedro
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 17.04.2025
• Subjects: Blood Coagulation - drug effects; chymase; Chymases - antagonists & inhibitors; Chymases - metabolism; Chymases - pharmacology; Fibrinolysin - metabolism; fibrinolysis; Fibrinolysis - drug effects; fulacimstat; Humans; Immunology; mast cells; Mast Cells - enzymology; plasmin; Recombinant Proteins - pharmacology; thrombolysis assay; Thrombosis - blood; fibrinolysis; thrombolysis assay; human blood clots; plasmin; chymase; human pulmonary emboli biopsies; fulacimstat; mast cells

Our group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of endogenous plasmin within thrombi. However, the impact of...