Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood - Vincent, Laurence; Lapointe, Catherine; McDonald, Patrick P.; Rammos, Christos; Rassaf, Tienush; Köllnberger, Maria; Tinel, Hanna; Heitmeier, Stefan; D’Orléans-Juste, Pedro (Frontiers in immunology, 2025)
Keywords: Blood Coagulation - drug effects; chymase; Chymases - antagonists & inhibitors; Chymases - metabolism; Chymases - pharmacology; Fibrinolysin - metabolism; fibrinolysis; Fibrinolysis - drug effects; fulacimstat; Humans; Immunology; mast cells; Mast Cells - enzymology; plasmin; Recombinant Proteins - pharmacology; thrombolysis assay; Thrombosis - blood; fibrinolysis; thrombolysis assay; human blood clots; plasmin; chymase; human pulmonary emboli biopsies; fulacimstat; mast cells