In vivo evaluation of focused ultrasound ablation surgery (FUAS)-induced coagulation using echo amplitudes of the therapeutic focused ultrasound transducer
Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required. The echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (...
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Published in | International journal of hyperthermia Vol. 41; no. 1; p. 2325477 |
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Format | Journal Article |
Language | English |
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Taylor & Francis Group
2024
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Abstract | Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required.
The echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (short pulse duration and low power) were found to correlate with the
coagulation. To further evaluate its coagulation prediction capabilities,
experiments were carried out. The liver, kidney, and leg muscles of three adult goats were treated using clinical FUAS settings, and the echo amplitude of the FUS transducer and grayscale in sonography before and after FUAS were collected. On day 7, animals were sacrificed humanely, and the treated tissues were dissected to expose the lesion. Echo amplitude changes and lesion areas were analyzed statistically, as were the coagulation prediction metrics.
The echo amplitude changes of the FUS transducer correlate well with the lesion areas in the liver (
= 0.682). Its prediction in accuracy (94.4% vs. 50%), sensitivity (92.9% vs. 35.7%), and negative prediction (80% vs. 30.8%) is better than sonography, but similar in specificity (80% vs. 100%) and positive prediction (100% vs. 100%). In addition, the correlation between tissue depth and the lesion area is not good (|
| < 0.2). Prediction performances in kidney and leg muscles are similar.
The FUS echo amplitudes are sensitive to the tissue properties and their changes after FUAS. They are sensitive and reliable in evaluating and predicting FUAS outcomes. |
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AbstractList | OBJECTIVEMonitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required.METHODThe echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (short pulse duration and low power) were found to correlate with the ex vivo coagulation. To further evaluate its coagulation prediction capabilities, in vivo experiments were carried out. The liver, kidney, and leg muscles of three adult goats were treated using clinical FUAS settings, and the echo amplitude of the FUS transducer and grayscale in sonography before and after FUAS were collected. On day 7, animals were sacrificed humanely, and the treated tissues were dissected to expose the lesion. Echo amplitude changes and lesion areas were analyzed statistically, as were the coagulation prediction metrics.RESULTSThe echo amplitude changes of the FUS transducer correlate well with the lesion areas in the liver (R = 0.682). Its prediction in accuracy (94.4% vs. 50%), sensitivity (92.9% vs. 35.7%), and negative prediction (80% vs. 30.8%) is better than sonography, but similar in specificity (80% vs. 100%) and positive prediction (100% vs. 100%). In addition, the correlation between tissue depth and the lesion area is not good (|R| < 0.2). Prediction performances in kidney and leg muscles are similar.CONCLUSIONThe FUS echo amplitudes are sensitive to the tissue properties and their changes after FUAS. They are sensitive and reliable in evaluating and predicting FUAS outcomes. Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required. The echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (short pulse duration and low power) were found to correlate with the coagulation. To further evaluate its coagulation prediction capabilities, experiments were carried out. The liver, kidney, and leg muscles of three adult goats were treated using clinical FUAS settings, and the echo amplitude of the FUS transducer and grayscale in sonography before and after FUAS were collected. On day 7, animals were sacrificed humanely, and the treated tissues were dissected to expose the lesion. Echo amplitude changes and lesion areas were analyzed statistically, as were the coagulation prediction metrics. The echo amplitude changes of the FUS transducer correlate well with the lesion areas in the liver ( = 0.682). Its prediction in accuracy (94.4% vs. 50%), sensitivity (92.9% vs. 35.7%), and negative prediction (80% vs. 30.8%) is better than sonography, but similar in specificity (80% vs. 100%) and positive prediction (100% vs. 100%). In addition, the correlation between tissue depth and the lesion area is not good (| | < 0.2). Prediction performances in kidney and leg muscles are similar. The FUS echo amplitudes are sensitive to the tissue properties and their changes after FUAS. They are sensitive and reliable in evaluating and predicting FUAS outcomes. AbstractObjective Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine fibroids). A more accurate and sensitive approach is required.Method The echo amplitudes of the focused ultrasound (FUS) transducer in a testing mode (short pulse duration and low power) were found to correlate with the ex vivo coagulation. To further evaluate its coagulation prediction capabilities, in vivo experiments were carried out. The liver, kidney, and leg muscles of three adult goats were treated using clinical FUAS settings, and the echo amplitude of the FUS transducer and grayscale in sonography before and after FUAS were collected. On day 7, animals were sacrificed humanely, and the treated tissues were dissected to expose the lesion. Echo amplitude changes and lesion areas were analyzed statistically, as were the coagulation prediction metrics.Results The echo amplitude changes of the FUS transducer correlate well with the lesion areas in the liver (R = 0.682). Its prediction in accuracy (94.4% vs. 50%), sensitivity (92.9% vs. 35.7%), and negative prediction (80% vs. 30.8%) is better than sonography, but similar in specificity (80% vs. 100%) and positive prediction (100% vs. 100%). In addition, the correlation between tissue depth and the lesion area is not good (|R| < 0.2). Prediction performances in kidney and leg muscles are similar.Conclusion The FUS echo amplitudes are sensitive to the tissue properties and their changes after FUAS. They are sensitive and reliable in evaluating and predicting FUAS outcomes. |
Author | Gong, Xiaobo Zhou, Yufeng You, Yaqing |
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References | e_1_3_5_29_1 e_1_3_5_28_1 e_1_3_5_27_1 e_1_3_5_26_1 e_1_3_5_25_1 e_1_3_5_24_1 e_1_3_5_45_1 e_1_3_5_3_1 e_1_3_5_2_1 e_1_3_5_40_1 Li F (e_1_3_5_23_1) 2006 e_1_3_5_42_1 e_1_3_5_43_1 e_1_3_5_9_1 e_1_3_5_21_1 e_1_3_5_8_1 e_1_3_5_20_1 e_1_3_5_5_1 e_1_3_5_4_1 e_1_3_5_7_1 e_1_3_5_6_1 e_1_3_5_18_1 e_1_3_5_17_1 e_1_3_5_39_1 e_1_3_5_16_1 e_1_3_5_15_1 e_1_3_5_37_1 e_1_3_5_13_1 e_1_3_5_14_1 e_1_3_5_35_1 e_1_3_5_11_1 e_1_3_5_34_1 e_1_3_5_12_1 Zhang T. (e_1_3_5_22_1) 2023 e_1_3_5_33_1 Li J (e_1_3_5_38_1) e_1_3_5_19_1 e_1_3_5_32_1 e_1_3_5_10_1 e_1_3_5_31_1 e_1_3_5_30_1 Zhang S (e_1_3_5_41_1) Chanel L-A (e_1_3_5_44_1) 2015 Kennedy JE (e_1_3_5_36_1) 2002 |
References_xml | – ident: e_1_3_5_4_1 doi: 10.1016/j.ultrasmedbio.2023.02.014 – ident: e_1_3_5_18_1 doi: 10.1088/0031-9155/53/6/018 – ident: e_1_3_5_9_1 doi: 10.1371/journal.pone.0118212 – ident: e_1_3_5_21_1 doi: 10.4103/JMU.JMU_3_17 – ident: e_1_3_5_24_1 doi: 10.1111/aogs.13159 – ident: e_1_3_5_10_1 doi: 10.1016/j.ultrasmedbio.2008.01.012 – ident: e_1_3_5_34_1 doi: 10.3390/s21041211 – ident: e_1_3_5_31_1 doi: 10.1016/j.ultrasmedbio.2014.07.021 – start-page: 151 volume-title: Cavitation in biomedicine ident: e_1_3_5_41_1 contributor: fullname: Zhang S – ident: e_1_3_5_6_1 doi: 10.3389/fneur.2022.880814 – ident: e_1_3_5_7_1 doi: 10.1016/j.diii.2014.02.002 – ident: e_1_3_5_8_1 doi: 10.4103/0973-1482.77064 – ident: e_1_3_5_33_1 doi: 10.1016/j.ultrasmedbio.2010.03.007 – ident: e_1_3_5_5_1 doi: 10.7150/jca.13906 – ident: e_1_3_5_19_1 doi: 10.1177/0161734618780430 – volume-title: 5th International Symposium on Therapeutic Ultrasound year: 2006 ident: e_1_3_5_23_1 contributor: fullname: Li F – ident: e_1_3_5_15_1 doi: 10.1186/s40349-017-0102-2 – ident: e_1_3_5_28_1 doi: 10.7150/ijms.8.9 – ident: e_1_3_5_37_1 doi: 10.1016/j.ejrad.2008.07.003 – ident: e_1_3_5_11_1 doi: 10.1016/S0301-5629(00)00279-9 – ident: e_1_3_5_17_1 doi: 10.1016/j.ultrasmedbio.2003.11.012 – volume-title: Ultrasound fundamentals, an evidence-based guide for medical practitioners ident: e_1_3_5_38_1 contributor: fullname: Li J – ident: e_1_3_5_29_1 doi: 10.1088/0031-9155/60/15/5911 – volume-title: 2nd International Symposium on Therapeutic Ultrasound year: 2002 ident: e_1_3_5_36_1 contributor: fullname: Kennedy JE – ident: e_1_3_5_14_1 doi: 10.1109/IEMBS.2008.4650204 – ident: e_1_3_5_25_1 doi: 10.1080/02656736.2018.1558290 – ident: e_1_3_5_30_1 doi: 10.1109/TUFFC.2014.006969 – volume-title: 37th annual international conference of the IEEE engineering in medicine and biology society (EMBC) year: 2015 ident: e_1_3_5_44_1 contributor: fullname: Chanel L-A – ident: e_1_3_5_26_1 doi: 10.1080/02656736.2021.1904152 – ident: e_1_3_5_32_1 doi: 10.1038/s41598-020-62363-7 – ident: e_1_3_5_2_1 doi: 10.5306/wjco.v2.i1.8 – ident: e_1_3_5_35_1 doi: 10.4103/abr.abr_114_19 – ident: e_1_3_5_43_1 doi: 10.1002/mrm.24695 – volume-title: Investigation of the evaluating the acoustic pathway and monitoring the therapeutic outcomes during focused ultrasound ablation surgery using the echo amplitudes [PhD thesis] year: 2023 ident: e_1_3_5_22_1 contributor: fullname: Zhang T. – ident: e_1_3_5_20_1 doi: 10.1016/j.ultrasmedbio.2023.03.002 – ident: e_1_3_5_45_1 doi: 10.1002/rcs.1793 – ident: e_1_3_5_12_1 doi: 10.1080/02656736.2022.2039788 – ident: e_1_3_5_40_1 doi: 10.1109/TBME.2009.2028133 – ident: e_1_3_5_27_1 doi: 10.1051/aacus/2022036 – ident: e_1_3_5_16_1 doi: 10.3390/app8112219 – ident: e_1_3_5_13_1 doi: 10.1097/MD.0000000000034684 – ident: e_1_3_5_42_1 doi: 10.1063/1.3131407 – ident: e_1_3_5_3_1 doi: 10.1016/j.diii.2018.03.001 – ident: e_1_3_5_39_1 doi: 10.1016/j.jimed.2022.06.004 |
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Snippet | Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in uterine... OBJECTIVEMonitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful coagulation in... AbstractObjective Monitoring sensitivity of sonography in focused ultrasound ablation surgery (FUAS) is limited (no hyperechoes in ∼50% of successful... |
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SubjectTerms | Animals Blood Coagulation coagulation prediction coagulative necrosis echo amplitude focused ultrasound (FUS) transducer Focused ultrasound ablation surgery FUAS Kidney - diagnostic imaging Kidney - surgery Liver - diagnostic imaging Liver - surgery sonography Transducers Ultrasonic Therapy |
Title | In vivo evaluation of focused ultrasound ablation surgery (FUAS)-induced coagulation using echo amplitudes of the therapeutic focused ultrasound transducer |
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