Oncogene-like addiction to aneuploidy in human cancers - Girish, Vishruth; Lakhani, Asad A.; Thompson, Sarah L.; Scaduto, Christine M.; Brown, Leanne M.; Hagenson, Ryan A.; Sausville, Erin L.; Mendelson, Brianna E.; Kandikuppa, Pranav K.; Lukow, Devon A.; Yuan, Monet Lou; Stevens, Eric C.; et al. (Science (American Association for the Advancement of Science), 2023)
Keywords: Addictions; Aneuploidy; Anticancer properties; Antitumor agents; Biocompatibility; Cancer; Carcinogenesis - genetics; Cell Cycle Proteins - genetics; Cell survival; Chromosome 1; Chromosomes; Copy number; CRISPR; Cytotoxicity; Dosage; Engineering; Exhibits; Gene Editing - methods; Gene expression; Genomes; Humans; In vivo methods and tests; Karyotypes; Kinases; Malignancy; Mutation; Neoplasms - genetics; Neoplasms - therapy; Nucleotide analogs; Nucleotides; Oncogenes; p53 Protein; Proto-Oncogene Proteins - metabolism; Sensitivity enhancement; Substance Abuse; Toxicity; Trisomy; Tumor cell lines; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumorigenesis; Tumors; Xenotransplantation